Caspase: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 10: | Line 10: | ||
===CASP-1=== | ===CASP-1=== | ||
[[3e4c]] – hpro-CASP (mutant) <br /> | [[3e4c]] – hpro-CASP (mutant) - human<br /> | ||
[[2nn3]] – pro-SfCASP (mutant) – Spodoptera frugiperda<br /> | [[2nn3]] – pro-SfCASP (mutant) – ''Spodoptera frugiperda''<br /> | ||
[[1sc1]], [[1sc4]] - hCASP (mutant) <br /> | [[1sc1]], [[1sc4]] - hCASP (mutant) <br /> | ||
[[1sc3]] - hCASP (mutant) + malonate<br /> | [[1sc3]] - hCASP (mutant) + malonate<br /> | ||
[[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]] - hCASP (mutant) + polypeptide inhibitor<br /> | [[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]] - hCASP (mutant) + polypeptide inhibitor<br /> | ||
[[2hbq]], [[1bmq]] - hCASP + inhibitor<br /> | [[2hbq]], [[1bmq]] - hCASP + inhibitor<br /> | ||
[[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], | [[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], [[2h48]], [[2fqq]], [[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[[[1rwv]], [[1rww]], [[1rwx]] - hCASP (mutant) + inhibitor<br /> | ||
[[1m72]] – SfCASP + polypeptide inhibitor<br /> | [[1m72]] – SfCASP + polypeptide inhibitor<br /> | ||
| Line 56: | Line 56: | ||
[[3h11]] - hCASP (mutant) + polypeptide inhibitor<br /> | [[3h11]] - hCASP (mutant) + polypeptide inhibitor<br /> | ||
[[2k7z]] – hpro-CASP (mutant) – NMR<br /> | [[2k7z]] – hpro-CASP (mutant) – NMR<br /> | ||
[[2fun]], [[1i4e]] – CASP + P35 – Autographa californica | [[2fun]], [[1i4e]] – CASP + P35 – ''Autographa californica'' | ||
===CASP-9=== | ===CASP-9=== | ||
Revision as of 10:56, 24 July 2011
Template:STRUCTURE 3d6f
Caspase (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis.
3D structures of caspase3D structures of caspase
CASP-1CASP-1
3e4c – hpro-CASP (mutant) - human
2nn3 – pro-SfCASP (mutant) – Spodoptera frugiperda
1sc1, 1sc4 - hCASP (mutant)
1sc3 - hCASP (mutant) + malonate
3d6f, 3d6h, 3d6m, 1ibc - hCASP (mutant) + polypeptide inhibitor
2hbq, 1bmq - hCASP + inhibitor
2h4w, 2h4y, 2h51, 2h54, 2hbr, 2hby, 2hbz, 2h48, 2fqq, 1rwk, 1rwm, 1rwn, 1rwo, 1rwp, [[1rwv, 1rww, 1rwx - hCASP (mutant) + inhibitor
1m72 – SfCASP + polypeptide inhibitor
CASP-2CASP-2
2p2c – hCASP
1pyo - hCASP + polypeptide inhibitor
CASP-3CASP-3
1qx3 - hCASP
3pcx, 3pd1, 3pd0, 3gjq, 3gjr, 3gjs, 3gjt, [[3edq, 3edr, 2cnk, 2cnl, 2cnn, 2cno, 2cdr, [[2h65, 1cp3, 1pau – hCASP + polypeptide inhibitor
2dko, 2cjx, 2cjy - hCASP (mutant) + polypeptide inhibitor
3kjf, 3h0e, 3deh, 3dei, 3dej, 3dek, 1re1, [[1rhj, 1rhk, 1rhm, 1rhq, 1rhr, 1rhu, 1nme, [[1nmq, 1nms, 1gfw – hCASP + inhibitor
3itn, 2j30, 2j31, 2j32, 2j33, 2c1e, 2c2k, [[2c2m, 2c2o, 2c2z, 2h5i, 2h5j – hpro-CASP + polypeptide inhibitor
1i3o - hCASP (mutant) + XIAP-BIR2
CASP-6CASP-6
3p45, 3k7e, 2wdp – hCASP
3nkf, 3nr2 – hCASP (mutant)
3od5 – hCASP + polypeptide inhibitor
CASP-7CASP-7
3rk5, 3ibf – hCASP
1k86 - hCASP (mutant)
1k88 – hpro-CASP (mutant)
3ibc, 2ql5, 2ql7, 2ql9, 2qlb, 2qlf, 2qlj, 1f1j - hCASP + polypeptide inhibitor
3h1p - hCASP (mutant) + polypeptide inhibitor
1shj, 1shl - hCASP (mutant) + inhibitor
1i51, 1kmc - hCASP (mutant) + XIAP-BIR2
1i4o - hCASP + XIAP
CASP-8CASP-8
3kjn, 3kjq – hCASP + inhibitor
1f9e, 1qtn, 1qdu - hCASP + polypeptide inhibitor
3h11 - hCASP (mutant) + polypeptide inhibitor
2k7z – hpro-CASP (mutant) – NMR
2fun, 1i4e – CASP + P35 – Autographa californica
CASP-9CASP-9
2ar9 – hCASP (mutant)
1jxq - hCASP + polypeptide inhibitor
1nw9 – hCASP catalytic domain + XIAP-BIR3
3ygs – hpro-CASP + APAF-1 CARD