Ferredoxin

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Ferredoxin (Fd) is found in chloroplasts which mediates electron transfer and contains an iron-sulfur cluster. It is involved in the photosynthesis process where its iron atoms accept or discharge electrons when they are being oxidized or reduced. The iron-sulfur cluster can contain 2Fe-2S and is termed plant-like or 3Fe-4S or 4Fe-4S clusters (e.g. 4Fe-4S Thermotoga maritima 1vjw to the right). Adrenodoxin (ADR) is a ferredoxin containing a 2Fe-2S group involved in electron transfer from NADPH+ to a cytochrome P-450 in the adrenal gland. Putidaredoxin (PUT) and terpredoxin (TER) are involved in the same reaction in bacteria and contain a 2Fe-2S group.

2Fe-2S containing ferredoxins2Fe-2S containing ferredoxins

2kaj, 1dox, 1doy – SyFd +Ga – Synechocystis – NMR
3hui – Fd – Rhodopseudomonas palustris
1off – SyFd
3gce – Fd – Nocardioides aromaticivorans
3lxf – Fd – Novosphingobium aromaticivorans
2e4p, 2e4q - Fd – Pseudomonas sp.
2q3w, 1vm9 - PmFd (mutant) – Pseudomonas mendocina
2i7f, 1uwm - RcFd – Rhodobacter capsulatus
1e9m – RcFd - NMR
1rfk, 3p63 - Fd – Cyanobacterium masticogladus laminosus
1vck - Fd – Pseudomonas resinovorans
1wri, 1frr - Fd – Equisetum arvense
1sjg - PmFd– NMR
1iue - Fd– Plasmodium falciparum
1m2a –AeFd – Aquifex aeolicus
1m2b, 1m2d, 1f37, 1f5b, 1f5c – AeFd (mutant)
1l5p – Fd – Trichomonas vaginalis
1i7h - Fd – Escherichia coli
1czp, 1qt9, 1frd, 1fxa - aFd– anabaena
1j7a, 1j7b, 1j7c , 1qoa, 1qob, 1qof, 1qog- aFd (mutant)
1e0z – Fd – Halobacterium salinarium
1pfd – Fd – Petroselinum crispum – NMR
1a70 - Fd (mutant) – Spinacia oleracea
1awd - Fd – Chlorella fusca
2cjn, 2cjo, 1roe – SyFd – NMR
1rof – SyFd – Synechococcus elongates
1doi - Fd – Haloarcula marismortui
4fxc – Fd – Spirulina platensis
1fxi – Fd – Aphanothece sacrum
3dqy, 2qpz - Fd – Pseudomonas putida
3ab5 – Fd – Cyanidioschyzon merolae

4Fe-4S containing ferredoxins4Fe-4S containing ferredoxins

3eun – AvFd – Allochromatium vinosum
3exy - AvFd (mutant)
2vkr - Fd+Zn – Acidianus ambivalens
2z8q - PfFd (mutant) – Pyrococcus furiosus
1siz - PfFd 2fgo - Fd– Pseudomonas aeruginosa
1iqz, 1ir0 - BtFd – Bacillus thermoproteolyticus
1rgv - Fd – Thauera aromatica
1dax, 1dfd – DaFd – Desulfovibrio africanus – NMR
1fxr - DaFd
1vjw – Fd – Thermotoga maritima

3Fe-4S containing ferredoxins3Fe-4S containing ferredoxins

2v2k – Fd – Mycobacterium smegmatis
1wtf - BtFd (mutant)
1sj1 - PfFd
1fxd - DgFd – Desulfovibrio gigas
1f2g – DgFd – NMR
1xer - Fd – Sulfolobus tokodaii

4Fe-4S+3Fe-4S containing ferredoxins4Fe-4S+3Fe-4S containing ferredoxins

1gao, 6fdr, 7fd1, 7fdr, 1axq, 6fd1, 1frh, 1fri,1frj, 1frk, 1frl, 1frm, 1fda, 1fdb, 1fdd, 5fd1, 1fer – AvFd – Azotobacter vinelandii
1pc4, 1pc5, 1g6b, 1g3o, 1ff2, 1b0v, 1d3w, 1b0t, 1a6l, 1ftc, 1frx, 2fd2, 1fd2 - AvFd (mutant)
1h98 – Fd – Thermus thermophilus
1a8p, 1bd6, 1bc6 - BsFd – Bacillus schlegelii – NMR

4Fe-4S+4Fe-4S containing ferredoxins4Fe-4S+4Fe-4S containing ferredoxins

1dur – Fd – Peptoniphilus asaccarolyticus
1bwe, 1bqx - BsFd (mutant) – NMR
2fdn, 1fca , 1fdn- Fd – Clostridium acidi-urici
1blu - Fd – Chromatium vinosum
1clf – Fd – Clostridium pasteurianum – NMR

AdrenoredoxinAdrenoredoxin

2jqr – ADR Fd domain (mutant)+cytochrome c (mutant) – yeast – NMR
2bt6 – cADR1 modified – cow
1l6u, 1l6v – cADR1 – NMR
1e6e – cADR (mutant)+ADR reductase
1cje, 1ayf - cADR
3na0 – hADR +cholesterol side-chain cleavage enzyme – human
3p1m - hADR

PutidaredoxinPutidaredoxin

1yji, 1yjj, 1pdx – PpPUT – Pseudomonas putida – NMR
3lb8 – PpPUT (mutant)+PUT reductase
1xln, 1xlo, 1xlp, 1xlq, 1r7s, 1oqq, 1oqr - PpPUT (mutant)
1gpx, 1put- PpPUT (mutant) - NMR

TerpredoxinTerpredoxin

1b9r – TER – Pseudomonas - NMR