ATPase: Difference between revisions

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{{STRUCTURE_1mo8|  PDB=1mo8  | SIZE=300| SCENE=ATPase/Cv/1 |right|CAPTION=ATPase [[1mo8]] }}
{{STRUCTURE_1mo8|  PDB=1mo8  | SIZE=300| SCENE=ATPase/Cv/1 |right|CAPTION=ATPase [[1mo8]] }}


[[ATPase]] catalyzes the breakdown of ATP to ADP and phosphate.  This reaction releases energy which is used by the cell in processes like moving solutes through molecular pumps against a gradient. NBD is the nucleotide binding domain. MBD is the metal binding domain. The images at the left and at the right correspond to one representative ATPase, ''i.e.'' the NMR structure of rat ATPase ([[1mo8]]).
[[ATPase]] is an enzyme which catalyzes the breakdown of ATP into ADP and a phosphate ion.  This dephosphorylation releases energy which the enzyme uses to drive other reactions. Vacuolar-type H+ ATPase (V-ATPase ) couples the energy to proton transport across membranes. The images at the left and at the right correspond to one representative ATPase, ''i.e.'' the NMR structure of rat ATPase ([[1mo8]]).


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[[3a3y]] - SaATPase+K+ouabain – ''Squalus acanthias''<br />
[[3a3y]] - SaATPase+K+ouabain – ''Squalus acanthias''<br />
[[3b8e]] - pATPase a+BeF3 - pig<br />
[[3kdp]], [[3b8e]] – pATPase  – pig <br />
[[3n23]] – pATPase + ouabain<br />
[[3b8e]] - pATPase a+BeF3 <br />
[[2hc8]] –AfATPase CopA A domain<br />
[[2hc8]] –AfATPase CopA A domain<br />
[[2b8e]] - AfATPase CopA NBD<br />
[[2b8e]] - AfATPase CopA NBD<br />
[[2xze]] - SaATPase<br />
[[2xze]] - SaATPase<br />
[[3kdp]], [[3b8e]] – pATPase  – pig <br />
[[1mo8]], [[1mo7]] - ATPase α-1 – rat<br />
[[1mo8]], [[1mo7]] - ATPase alpha-1 – rat<br />
[[1q3i]] - pATPase NBD  
[[1q3i]] - pATPase NBD  


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[[2zbf]] - rATPase+BeF3+TG<br />
[[2zbf]] - rATPase+BeF3+TG<br />
[[2zbg]] - rATPase+AlF4+TG<br />
[[2zbg]] - rATPase+AlF4+TG<br />
[[2zbd]] - rATPase+AlF4+ADP+Ca<br />
[[2zbd]], [[3ar8]] - rATPase+AlF4+nucleotide+Ca<br />
[[2dqs]] - rATPase+AMPPCP<br />
[[3ar9]] - rATPase+BeF3+nucleotide<br />
[[2c88]], [[2c8k]] - rATPase+AMPPCP+TG<br />
[[2dqs]], [[3ar2]], [[1vfp]] - rATPase+AMPPCP<br />
[[1vfp]] - rATPase+AMPPCP<br />
[[2c88]], [[2c8k]], [[3ar4]], [[3ar3]], [[3ar5]], [[3ar7]] - rATPase+nucleotide+TG<br />
[[2ear]], [[2c8l]] - rATPase+TG<br />
[[2ear]], [[2c8l]] - rATPase+TG<br />
[[1iwo]] - rATPase<br />
[[1iwo]] - rATPase<br />
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[[1iwc]], [[1iwf]] - pATPase NBD <br />
[[1iwc]], [[1iwf]] - pATPase NBD <br />
[[3ixz]] - pATPase a+AlF4
[[3ixz]] - pATPase a+AlF4<br />
 
[[2xzb]] – pATPase subunits α, β<br />


=== Mg transporting ATPase ===
=== Mg transporting ATPase ===
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[[2zd2]] – PdATPase (mutant) ATP12<br />
[[2zd2]] – PdATPase (mutant) ATP12<br />
[[1d8s]] – EcATPase F1<br />
[[1d8s]] – EcATPase F1<br />
[[1vdz]] – ATPase subunit A – ''Pyrococcus horikoshii''
[[1vdz]] – ATPase subunit A – ''Pyrococcus horikoshii''<br />
 
===V-ATPase===
 
[[2kz9]] – yV-ATPase subunit E - NMR<br />


[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:52, 20 March 2011

File:1mo8.png
NMR Structure of ATPase 1mo8

Template:STRUCTURE 1mo8

ATPase is an enzyme which catalyzes the breakdown of ATP into ADP and a phosphate ion. This dephosphorylation releases energy which the enzyme uses to drive other reactions. Vacuolar-type H+ ATPase (V-ATPase ) couples the energy to proton transport across membranes. The images at the left and at the right correspond to one representative ATPase, i.e. the NMR structure of rat ATPase (1mo8).

3D Structures of ATPase3D Structures of ATPase

Cu transporting ATPaseCu transporting ATPase

2kmv, 2kmx, 2arf – hATPase NBD – human – NMR
2kij - hATPase MBD – NMR
1yjr, 1yjt, 1yju, 1yjv - hATPase (mutant) 6th soluble domain – NMR
1y3j, 1y3k - hATPase 5th soluble domain – NMR
1s6o, 1s6u - hATPase 2nd soluble domain – NMR
1q8l - hATPase 2nd MBD – NMR
1aw0, 2aw0 - hATPase 4th MBD – NMR
1kvi, 1kvj - hATPase 1st MBD – NMR
3dxs - AtATPase MBD – Arabidopsis thaliana
2k1r - hATPase MBD+ ATOX1 – NMR
2rop, 2g9o, 2ga7 - hATPase MBD – NMR
2rml - BsATPase N-terminal – Bacillus subtilis – NMR
2gcf - sATPase N-terminal - Synechocystis – NMR
2iye - ATPase catalytic fragment – Sulfolobus solfataricus
1fvq, 1fvs - hATPase – NMR


Na/K transporting ATPaseNa/K transporting ATPase

3a3y - SaATPase+K+ouabain – Squalus acanthias
3kdp, 3b8e – pATPase – pig
3n23 – pATPase + ouabain
3b8e - pATPase a+BeF3
2hc8 –AfATPase CopA A domain
2b8e - AfATPase CopA NBD
2xze - SaATPase
1mo8, 1mo7 - ATPase α-1 – rat
1q3i - pATPase NBD


Ca transporting ATPaseCa transporting ATPase

3fgo - rATPase+CPA+AMPPCP – rabbit
3b9r, 1xp5 - rATPase+AlF4
1wpg - rATPase+MgF4
2zbe – rATPase+BeF3
2zbf - rATPase+BeF3+TG
2zbg - rATPase+AlF4+TG
2zbd, 3ar8 - rATPase+AlF4+nucleotide+Ca
3ar9 - rATPase+BeF3+nucleotide
2dqs, 3ar2, 1vfp - rATPase+AMPPCP
2c88, 2c8k, 3ar4, 3ar3, 3ar5, 3ar7 - rATPase+nucleotide+TG
2ear, 2c8l - rATPase+TG
1iwo - rATPase
2agv - rATPase+TG+BHQ
2eas - rATPase+CPA
2eat - rATPase+CPA+GT
2eau - rATPase+CPA+curcumin
3ba6 - rATPase phosphoenzyme intermediate
3fpb - rATPase+ATP+cyclopiazonic acid
3fps, 2oa0 - rATPase+ADP+cyclopiazonic acid
2o9j - rATPase+MgF4+cyclopiazonic acid
1kju - rATPase E2 state
2c9m - rATPase Ca2E1 state
1t5s - rATPase Ca2E1 state+AMPPCP
1t5t - rATPase Ca2E1 state+ADP+AlF4
1su4 - rATPase +2Ca2
2by4 - rATPase HNE2 state+thapsigargin derivative


Zn transporting ATPaseZn transporting ATPase

2ofg, 2ofh - sATPase N-terminal – NMR


K+ transporting ATPaseK+ transporting ATPase

2a00, 2a29 - EcATPase NBD of KdpB+AMPPNP– Escherichia coli – NMR
1svj, 1u7q - EcATPase NBD of KdpB – NMR


As transporting ATPaseAs transporting ATPase

1ii0, 1f48 - EcATPase
1ihu – EcATPase+Mg+ADP+AlF3
1ii9 - EcATPase+AMPPNP


H+ transporting ATPaseH+ transporting ATPase

3b8c - AtATPase C terminal truncated
1mhs - ATPase – Neurospora crassa

Na+ transporting ATPaseNa+ transporting ATPase

2db4 - ATPase subunit K – Enterococcus hirae
1yce - ATPase rotor ring – Ilyobacter tartaricus

H/K transporting ATPaseH/K transporting ATPase

1iwc, 1iwf - pATPase NBD
3ixz - pATPase a+AlF4
2xzb – pATPase subunits α, β

Mg transporting ATPaseMg transporting ATPase

3gwi – EcATPase P-1 NBD


Arg/ornithine transporting ATPaseArg/ornithine transporting ATPase

3md0 – MtATPase+GDP – Mycobacterium tuberculosis
1kmh - ATPase alpha subunit+tentoxin – spinach
1h8e – cATPase+ADP+AlF4+ADP+SO4 - cow
1h8h - cATPase+ AMPPNP
1efr - cATPase+efrapeptin
3fks – ATPase – yeast
3ea0 – ATPase ParA, fragment – Chlorobium tepidum
2qen – ATPase (mutant) Walker-type – Pyrococcus abyssi
3cf0, 3cf1, 3cf3 – mATPase NBD+ADP – mouse
3cf2 - mATPase NBD+ADP+AMP-PNP
2r31, 2p4x – PdATPase ATP12 – Paracoccus denitrificans
2zd2 – PdATPase (mutant) ATP12
1d8s – EcATPase F1
1vdz – ATPase subunit A – Pyrococcus horikoshii

V-ATPaseV-ATPase

2kz9 – yV-ATPase subunit E - NMR

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Alexander Berchansky, Jaime Prilusky, Michal Harel, Wayne Decatur, Mark Hoelzer, Karsten Theis
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