Rac: Difference between revisions

Revision as of 21:48, 22 September 2017

Function

The small G-protein Rac or Ras-related C3 botulinum toxin substrate. Ras1 is involved in the regulation of cytoskeletal organization, cell adhesion, migration and morphological changes^[1]. Ras3 binds to a variety of effector proteins to regulate cellular responses like cell spreading and the formation of actin-based protrusions.

Disease

Mutations in Rac2 are associated with neutrophil immunodeficiency syndrome.

Structural highlights

The interactions between Rac1 and YpkA are via ^[2]. .

Human Rac1 (magenta) complex with YpkA (cyan), GDP and Mg+2 ion (green) (PDB code 2h7v)

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3D structures of Rac3D structures of Rac

Updated on 22-September-2017

ReferencesReferences

↑ Asahara S, Shibutani Y, Teruyama K, Inoue HY, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y. Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Diabetologia. 2013 May;56(5):1088-97. doi: 10.1007/s00125-013-2849-5. Epub 2013, Feb 15. PMID:23412604 doi:http://dx.doi.org/10.1007/s00125-013-2849-5
↑ Prehna G, Ivanov MI, Bliska JB, Stebbins CE. Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors. Cell. 2006 Sep 8;126(5):869-80. PMID:16959567 doi:10.1016/j.cell.2006.06.056

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Asahara S, Shibutani Y, Teruyama K, Inoue HY, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y. Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Diabetologia. 2013 May;56(5):1088-97. doi: 10.1007/s00125-013-2849-5. Epub 2013, Feb 15. PMID:23412604 doi:http://dx.doi.org/10.1007/s00125-013-2849-5

[2] Prehna G, Ivanov MI, Bliska JB, Stebbins CE. Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors. Cell. 2006 Sep 8;126(5):869-80. PMID:16959567 doi:10.1016/j.cell.2006.06.056

[1]

[2]

@@ Line 23: / Line 23: @@
 **[[4gzm]] – hRac1 (mutant) + GSP <br />
 **[[5hzh]], [[2wkp]], [[2wkq]], [[2wkr]] – hRac1 LOV2 domain (mutant) + GTP + MFN <br />
+**[[5vcu]] - Rac1 + GDP - ''Naegleria fowleri''<br />
 *Rac1 complex with protein
@@ Line 33: / Line 34: @@
 **[[2nz8]] – hRac1 + triple functional domain protein<br />
 **[[1foe]] – hRac1 + TIAM1 <br />
+**[[2nz8]] - hRac1 + TRIO N-terminal<br />
 *Rac1 complex with protein and nucleotide
@@ Line 47: / Line 49: @@
 **[[1he1]] – hRac1 + GTPase-activating protein + GDP <br />
 **[[1e96]] – hRac1 (mutant) + neutrophil cytosol factor 2 + GTP <br />
+**[[5o33]] - hRac1 + kalirin + GDP<br />
 *Rac2