Deoxyuridine 5'-triphosphate nucleotidohydrolase: Difference between revisions

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{{STRUCTURE_1smc|  PDB=1smc | SIZE=400| SCENE= |right|CAPTION= dUTPase trimer complex with dUTP, nitrate and Tris buffer [[1smc]] }}
 
 
<StructureSection load='1smc' size='350' side='right' caption='dUTPase trimer complex with dUTP (stick model), nitrate and Tris (PDB entry [[1smc]])' scene=''>


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'''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi).  DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. DUTP inhibitors are being tested as possible anti-bacterial agents targeting diseases like malaria, leishmaniasis, tuberculosis and trypanosomiasis.  Prokaryotic DUTP contains metal ion.
== Function ==
 
'''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi).  DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway.  
Prokaryotic DUTP contains metal ion. <ref>PMID:11742345</ref>
 
== Relevance ==


DUTP inhibitors are being tested as possible anti-bacterial agents targeting diseases like malaria, leishmaniasis, tuberculosis and trypanosomiasis. 
</StructureSection>
==3D structures of dUTPase==
==3D structures of dUTPase==


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**[[4aoo]], [[4apz]], [[4aoz]] - BsDUTP + Mg + PPi + uridine<br />
**[[4aoo]], [[4apz]], [[4aoz]] - BsDUTP + Mg + PPi + uridine<br />
}}
}}
== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:11, 23 December 2015



Function

Deoxyuridine 5’-triphosphate nucleotidohydrolase (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway.

Prokaryotic DUTP contains metal ion. [1]

Relevance

DUTP inhibitors are being tested as possible anti-bacterial agents targeting diseases like malaria, leishmaniasis, tuberculosis and trypanosomiasis.

dUTPase trimer complex with dUTP (stick model), nitrate and Tris (PDB entry 1smc)

Drag the structure with the mouse to rotate

3D structures of dUTPase3D structures of dUTPase

Updated on 23-December-2015

ReferencesReferences

  1. ↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742

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Michal Harel, Alexander Berchansky
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