Cluster of Differentiation CD38

Cluster of Differentiation 38 (CD38), known also as ADP-ribosyl cyclase 1 (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca++ signaling.

3D Structures of Cluster of Differentiation 383D Structures of Cluster of Differentiation 38

Updated on 12-March-2015

CD38CD38

3gc6 – bCD38 - bovine
3gh3, 3ghh – bCD38 residues 32-278
2eg9 - CD38 enzymatic domain (mutant) – mouse
2ef1 - hCD38 enzymatic domain – human
1yh3 - hCD38 enzymatic domain (mutant)
1zvm - hCD38 (mutant)

• • 1isf – hADPRC2 (mutant)
    

CD38+ligandCD38+ligand

3i9m, 3i9n – hCD38 enzymatic domain+ADPR analog
3f6y – hCD38 enzymatic domain+Ca++
3dzf - hCD38 enzymatic domain+intermediate
3dzg - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex
3dzh - hCD38 enzymatic domain (mutant)+GTP
3dzi - hCD38 enzymatic domain (mutant)+intermediate/GTP complex
3dzj, 3dzk - hCD38 enzymatic domain (mutant)+NMN complex
2pgj, 2pgl - hCD38 enzymatic domain (mutant)+substrate analog
2o3t - hCD38 enzymatic domain (mutant)+cGDPR
3u4h, 3u4i - hCD38 enzymatic domain (mutant)+cIDPR
2o3u - hCD38 enzymatic domain (mutant)+NGD
2o3q, 2o3r, 2o3s - hCD38 enzymatic domain (mutant)+cADPR
4f45 - hCD38 enzymatic domain (mutant)+ NAADP
4f46 - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP
2i65 – hCD38+NAD
2i66 - hCD38 (mutant)+GDP intermediate
2i67 - hCD38 (mutant)+ADPR
2hct - hCD38 enzymatic domain (mutant)+NMN
3ofs - hCD38 enzymatic domain (mutant)+ ARA-2 F-ADPR
3raj - hCD38 enzymatic domain (mutant)+ FAB
3rok, 3rom - hCD38 (mutant) + arabinitol derivative
3roq - hCD38 (mutant) + hydrofuran derivative
3rop - hCD38 (mutant) + arabinitol derivative + nicotinamide
1isf – hCD38 (mutant)