Transcription initiation factor

Transcription initiation factors (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process. TFIIA is one of several TFs which are required for transcription. TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA. TFIIB bridges between TFIID and RNA polymerase II. TFIID recognizes the promoter sequence on the DNA. TFIIF binds RNA polymerase III prohibiting it to bind to DNA outside the promoter. 3D structures of transcription initiation factors Updated on 05-May-2025 TFIIA 1ytf, 1nh2, 1rm1 – yTFIIA + TBP + DNA – yeast 1nvp – hTFIIA + TATA-binding protein + DNA – human TFIIB 1pft – TFIIB N terminal – Pyrococcus furiosus – NMR 1tfb – hTFIIB - NMR 1dl6 - hTFIIB N terminal – NMR 1rly - hTFIIB Zn ribbon domain + Zn – NMR 1ro4 - hTFIIB Zn ribbon domain – NMR 1vol, 1c9b – hTFIIB + TBP + DNA 3k1f, 3k7a, 4bbr, 4bbs – yTFIIB + RNA polymerase II 1ais, 1d3u - TFIIB C terminal + TBP + DNA – Pyrococcus woesei TFIID 1bh8 – hTFIID 1eqf – hTFIID subunit 1 3uv5, 3uv4 – hTFIID subunit 1 bromodomain 3aad – hTFIID subunit 1 bromodomain + histone chaperone ASF1A 1tba – TFIID – Drosophila melanogaster - NMR 1bh9 – hTFIID + PCMBS 1qn3, 1qn4, 1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc, 1qne – TFIID + DNA – Arabidopsis thaliana TFIIE 1vd4 - hTFIIB Zn finger domain – NMR 2rnq – hTFIIE C terminal - NMR 2rnr – hTFIIE C terminal + TFIIH PH domain- NMR TFIIF 1f3u – hTFIIF 1nha – hTFIIF C terminal - NMR 1i27 – hTFIIF C terminal (mutant) 1j2x – hTFIIF C terminal + RNA polymerase CTD phosphatase peptide 1onv – hTFIIF C terminal + serine phosphatase peptide - NMR 2k7l – hTFIIF C terminal + FCP1 peptide - NMR

spinqualitylabelsall models Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry 1vol) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image