Clp protease 3D structures: Difference between revisions

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*Clp P subunit or ATP-dependent Clp protease proteolytic subunit
*Clp P subunit or ATP-dependent Clp protease proteolytic subunit


**[[1tg6]] - hClpP – human<br />
**[[1tg6]], [[8w7c]] - hClpP – human<br />
**[[1tyf]], [[1yg6]] – EcClpP  – ''Escherichia coli''<br />
**[[1tyf]], [[1yg6]] – EcClpP  – ''Escherichia coli''<br />
**[[1yg8]], [[3hln]] - EcClpP  (mutant) <br />
**[[1yg8]], [[3hln]] - EcClpP  (mutant) <br />
**[[1y7o]] – SpClpP – ''Streptococcus pneumonia''<br />
**[[1y7o]] – SpClpP – ''Streptococcus pneumonia''<br />
**[[2f6i]], [[4gm2]], [[4hnk]] – ClpP  – ''Plasmodium falciparum''<br />
**[[2f6i]], [[4gm2]], [[4hnk]] – ClpP  – ''Plasmodium falciparum''<br />
**[[2cby]], [[2ce3]], [[2c8t]], [[4u0h]], [[5e0s]], [[5dzk]] - MtClpP – ''Mycobacterium tuberculosis''<br />
**[[2cby]], [[2ce3]], [[2c8t]], [[4u0h]], [[5e0s]], [[5dzk]] – MtClpP1 + ClpP2 – ''Mycobacterium tuberculosis''<br />
**[[6vgk]] – MtClpP1 + ClpP2 – Cryo EM<br />
**[[6mx2]] – CdClpP1 - ''Clostridium difficile'' <br />
**[[6mx2]] – CdClpP1 - ''Clostridium difficile'' <br />
**[[3ktg]], [[3kth]], [[3tt6]] – BsClpP – ''Bacillus subtilis''<br />
**[[3ktg]], [[3kth]], [[3tt6]] – BsClpP – ''Bacillus subtilis''<br />
**[[7feq]], [[7fes]] - BsClpP – Cryo EM<br />
**[[7feq]], [[7fes]] - BsClpP – Cryo EM<br />
**[[3q7h]] - ClpP – ''Coxiella burnetii''<br />
**[[3q7h]] - ClpP – ''Coxiella burnetii''<br />
**[[3qwd]], [[3st9]], [[3sta]], [[3v5e]], [[4emm]], [[4mxi]] - SaClpP – ''Staphylococcus aureus''<br />
**[[3qwd]], [[3st9]], [[3sta]], [[3v5e]], [[4emm]], [[4mxi]], [[6tty]] - SaClpP – ''Staphylococcus aureus''<br />
**[[3v5i]], [[4emp]], [[5c90]], [[6dkf]] - SaClpP (mutant) <br />
**[[3v5i]], [[4emp]], [[5c90]], [[6dkf]] - SaClpP (mutant) <br />
**[[8cj4]] - SeClpP – ''Staphylococcus epidermidis''<br />
**[[2zl0]] - HpClpP – ''Helicobacter pylori''<br />
**[[2zl0]] - HpClpP – ''Helicobacter pylori''<br />
**[[2zl3]] - HpClpP (mutant) <br />
**[[2zl3]] - HpClpP (mutant) <br />
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**[[6naq]] – NmClpP – ''Neisseria meningitidis''<br />
**[[6naq]] – NmClpP – ''Neisseria meningitidis''<br />
**[[7kr2]] - NmClpP – Cryo EM<br />
**[[7kr2]] - NmClpP – Cryo EM<br />
**[[6pbu]] – ClpP – ''Mycobacterium smegmatis'' <br />
**[[6naw]], [[6nay]] - NmCLP (mutant)<br />
**[[7m1l]], [[7m1m]] – ClpP – ''Pseudomonas aeruginosa'' <br />
**[[6pbu]] – MsClpP – ''Mycobacterium smegmatis'' <br />
**[[7m1l]], [[7m1m]] – PaClpP – ''Pseudomonas aeruginosa'' <br />
**[[6x60]] – ClpP2 – ''Chlamydia trachomatis'' <br />
**[[6x60]] – ClpP2 – ''Chlamydia trachomatis'' <br />
**[[7dft]] – XoClpP – ''Xanthomonas oryzae''<br />
**[[7dft]] – XoClpP – ''Xanthomonas oryzae''<br />
**[[8xn4]] – ShClpP (mutant) – ''Streptomyces hawaiiensis'' – Cryo EM<br />


*Clp P subunit binary complex
*Clp P subunit binary complex


**[[6h23]] - hClpP (mutant) + carboxamide derivative<br />
**[[6h23]] - hClpP (mutant) + carboxamide derivative<br />
**[[6dl7]], [[7vp9]], [[7wh5]] - hClpP + pyrimidine derivative<br />
**[[6dl7]], [[6nb1]], [[7uvm]], [[7uvn]], [[7uvr]], [[7uvu]], [[7vp9]], [[7wh5]], [[8i7x]], [[8wuz]], [[8ylb]] - hClpP + pyrimidine derivative<br />
**[[7uw0]], [[8hgk]] – hClpP + inhibitor<br />
**[[6bba]] - hClpP + ADEP-28<br />
**[[6bba]] - hClpP + ADEP-28<br />
**[[8w7e]] – hClpP + activator<br />
**[[2fzs]], [[3mt6]] - EcClpP + ADEP-1<br />
**[[2fzs]], [[3mt6]] - EcClpP + ADEP-1<br />
**[[6ppe]] – EcClpP + ClpX – Cryo EM<br />
**[[7mk5]], [[8szm]] – EcClpP + inhibitor<br />
**[[7mk5]] – EcClpP + inhibitor<br />
**[[6hwm]] – EcClpP + drug <br />
**[[8qyf]] – SeClpP + drug <br />
**[[2zl2]] - HpClpP + peptide<br />
**[[2zl2]] - HpClpP + peptide<br />
**[[2zl4]] - HpClpP (mutant) + peptide<br />
**[[2zl4]] - HpClpP (mutant) + peptide<br />
**[[3kti]], [[3ktj]], [[3ktk]] - BsClpP + ADEP-1<br />
**[[3kti]], [[3ktj]], [[3ktk]] - BsClpP + ADEP-1<br />
**[[3tt7]] - BsClpP + DFP<br />
**[[3tt7]] - BsClpP + DFP<br />
**[[4u0g]] – MtClpP + ADEP + agonist<br />
**[[6iw7]] – MtClpP1 + ClpP2 + drug <br />
**[[5dl1]], [[6l40]] – SaClpP + inhibitor<br />
**[[7x8x]] – MtClpP1 + ClpP2 + inhibitor <br />
**[[6vgn]] – MtClpP1 +  ClpP2 + ADEP <br />
**[[6vgq]] – MtClpP1 + ClpP2 + peptide – Cryo EM<br />
**[[5dl1]], [[6l3x]], [[6l40]], [[6n80]], [[8e71]], [[8e7p]], [[8oll]], [[8r03]], [[8r04]], [[9irm]], [[9irp]] – SaClpP + inhibitor<br />
**[[8ef8]] – SaClpP (mutant) + inhibitor<br />
**[[5w18]], [[5vz2]], [[6pka]], [[6pmd]] – SaClpP + peptide<br />
**[[5w18]], [[5vz2]], [[6pka]], [[6pmd]] – SaClpP + peptide<br />
**[[7wgs]], [[7wid]], [[7xbz]] – SaClpP + activator<br />
**[[7wgs]], [[7wid]], [[7xbz]] – SaClpP + activator<br />
**[[6ttz]] – SaClpP + ADEP-4<br />
**[[5dkp]] – NmClpP + ADEP <br />
**[[5dkp]] – NmClpP + ADEP <br />
**[[6nah]] - NmClpP + ADEP-14<br />
**[[6nah]] - NmClpP + ADEP-14<br />
**[[6w9t]], [[8szn]] – NmClpP + inhibitor<br />
**[[8dla]] – CtClpP2 + inhibitor<br />
**[[8r05]] – ClpP + inhibitor – ''Photorhabdus laumondii''<br />
**[[7fep]], [[7fer]] – BsClpP + ADEP1 – Cryo EM <br />
**[[7fep]], [[7fer]] – BsClpP + ADEP1 – Cryo EM <br />
**[[7p80]], [[7p81]] – BsClpP + ADEP2<br />
**[[7p80]], [[7p81]] – BsClpP + ADEP2<br />
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**[[7dfu]] – XoClpP + ADEP-4 <br />
**[[7dfu]] – XoClpP + ADEP-4 <br />
**[[6hwn]] – ClpP + tripeptide – ''Thermus thermophilus''<br />
**[[6hwn]] – ClpP + tripeptide – ''Thermus thermophilus''<br />
**[[8xop]] – ShClpP (mutant) + ADEP-1 – Cryo EM<br />


*CLP C
*Clp P subunit higher complexes


**[[5gui]] – ClpC1 N terminal – ''Arabidopsis thaliana'' <br />
**[[4u0g]] – MtClpP1 + ClpP2 + ADEP + agonist<br />
**[[6emw]] – SaClpP in MECA complex – Cryo EM <br />
**[[8xon]], [[8xoo]] – ShClpP (mutant) + casein + ketoreductase – Cryo EM<br />
**[[7eko]], [[7ekq]] – ClpP in chloroplast complex – ''Chlamydomonas reinhardtii'' – Cryo EM <br />
 
*Clp C
 
**[[8xqu]] – hClpC1 N terminal <br />
**[[5gui]] – AtClpC1 N terminal – ''Arabidopsis thaliana'' <br />
**[[3fes]] - CdClpC <br />
**[[3fes]] - CdClpC <br />
**[[6pbq]] - MtClp N-terminal domain<br />
**[[6pbq]], [[8b9u]] - MtClp N-terminal domain<br />
**[[8a8u]], [[8a8v]], [[8a8w]] - MtClp + antibiotic + ADP<br />
**[[8a8u]], [[8a8v]], [[8a8w]] - MtClp + antibiotic + ADP<br />
**[[6cn8]], [[6pbs]] - MtClp N-terminal domain 1-145 + antibiotics<br />
**[[6cn8]], [[6pbs]] - MtClp N-terminal domain 1-145 + antibiotics<br />
**[[8otk]] - BsClp N-terminal domain (mutant)<br />
**[[8b3s]] - BsClp N-terminal domain + YJBA<br />
**[[6em8]], [[6em9]] - SaClp – Cryo EM<br />
**[[6em8]], [[6em9]] - SaClp – Cryo EM<br />
**[[8p66]] - PaClpC - NMR<br />
*Clp S or ATP-dependent Clp protease adapter protein ClpS
**[[7d34]] – AtClpS1 + dipeptide<br />
**[[9ayn]], [[9ayp]], [[9az5]] - MsClp <br />
**[[9b06]] - MsClp + Thr<br />
**[[9ayo]], [[9b10]], [[9b1p]] - MsClp + dipeptide<br />


*Clpx or ATP-dependent Clp protease ATP-binding subunit ClpXP
*Clp X or ATP-dependent Clp protease ATP-binding subunit ClpXP


**[[6pba]] - MtClp N-terminal domain<br />
**[[6pba]] - MtClp N-terminal domain<br />
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**[[6pp5]] - EcClp + ADP – Cryo EM<br />
**[[6pp5]] - EcClp + ADP – Cryo EM<br />
**[[6pp6]], [[6pp7]], [[6pp8]] - EcClp + ADP + ATPgS – Cryo EM<br />
**[[6pp6]], [[6pp7]], [[6pp8]] - EcClp + ADP + ATPgS – Cryo EM<br />
**[[9c87]], [[9c88]] - EcClp + DHFR + ADP + ATP – Cryo EM<br />
**[[8v9r]] - EcClp + DHFR + ADP + ATP + methotrexate – Cryo EM<br />
**[[6sfw]] - LmClp - Cryo EM<br />
**[[6sfw]] - LmClp - Cryo EM<br />
**[[6lsy]] - SpClp - Cryo EM<br />
**[[6lsy]] - SpClp - Cryo EM<br />
**[[6lt4]] - SpClp + ATPgS – Cryo EM<br />
**[[6lt4]] - SpClp + ATPgS – Cryo EM<br />


For CLP A subunit and CLP N see [[Heat Shock Proteins]] Hsp100
*ClpP+ClpX
 
**[[6ppe]], [[6wr2]], [[8e7v]] – EcClpP + ClpX – Cryo EM<br />
**[[6po1]], [[6wsg]] – EcClpP + ClpX + ATP-gS – Cryo EM<br />
**[[8e91]] – EcClpP + ClpX + ADP + ATP-gS – Cryo EM<br />
**[[8e8q]] – EcClpP + ClpX (mutant) + ADP + ATP – Cryo EM<br />
**[[6po3]], [[6pod]], [[6pos]] – EcClpP + ClpX + peptide + ADP + ATP-gS – Cryo EM<br />
**[[6wrf]] – EcClpP + ClpX + GFP + ADP + ATP-gS – Cryo EM<br />
**[[8et3]] – EcClpP + ClpX + GFP + SSPB + ADP + ATP-gS – Cryo EM<br />
**[[6vfs]], [[6vfx]] – NmClpP + ClpX + peptide + ADP + ATP – Cryo EM<br />
**[[6vxf]] - NmClpP + ClpX + ADP + ATP – Cryo EM<br />
 
*ClpP+ClpA
 
**[[6uqe]], [[6uqo]], [[6w1z]], [[6w20]], [[6w21]], [[6w23]] – EcClpP + ClpA + RepA + ADP + ATP – Cryo EM<br />
 
*ClpP+ClpA+ClpS
 
**[[7uiv]], [[7uiw]], [[7uix]], [[7uiy]], [[7uiz]], [[7uj0]] – EcClpP + ClpA + ClpS + ADP + ATP-gS – Cryo EM<br />
 
For Clp A subunit and Clp N see [[Heat Shock Proteins]] Hsp100


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Latest revision as of 13:22, 2 February 2025

3D structures of Clp protease3D structures of Clp protease

Updated on 02-February-2025

For Clp A subunit and Clp N see Heat Shock Proteins Hsp100

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel
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