Activation of mitochondrial Caseinolytic Protease P (ClpP) induces selective cancer cell lethalityActivation of mitochondrial Caseinolytic Protease P (ClpP) induces selective cancer cell lethality

Structural highlights

8w7c is a 7 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CLPP_HUMAN Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.

8w7c, resolution 3.00Å

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OCA