Symporter 3D structures

Updated on 11-December-2023 - For a general description of the protein see Symporter

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• D-xylose/H+ symporter
  • 4ja4, 4qiq – EcSymp – Escherichia coli
    
  • 4ja3, 6n3i – EcSymp (mutant)
    
  • 4gby – EcSymp + xylose
    
  • 4gbz, 4gc0 – EcSymp + glucose derivative
    
• Galactonate-proton symporter
  • 6e9o – EcSymp (mutant) + galactonate
    
  • 6e9n – EcSymp + gluconate
    
• Di-or tripeptide/H+ symporter
  • 4ja4, 4xni, 4xnj, 4d2b, 4aps, 5d6k, 5mmt, 5d6k, 5oxo, 5oxp, 5oxq, 6eia, 6fmr, 6fmy, 6yog, 6yof, 7ac6 – StSymp – Streptococcus thermophilus
    
  • 4d2d, 6ghj – StSymp + tripeptide
    
  • 4d2c, 5d58, 5d59, 5oxk, 5oxl, 5oxm, 5oxn – StSymp + dipeptide
    
• Oligopeptide/H+ symporter
  • 4lep, 4tph, 6jkc, 6jkd – SoSymp – Shewanella oneidensis
    
  • 6ji1 – SoSymp – Cryo EM
    **2xut – SoSymp (mutant)
    
  • 4tpg, 4tpj – SoSymp + tripeptide
    
• Bile acid/Na+ symporter
  • 4n7w – YfSymp – Yersinia frederiksenii
    
  • 4n7x, 7cyg, 7cyk – YfSymp (mutant)
    
  • 3zuy – Symp - Neisseria meningitidis
    
  • 3zux – Symp (mutant)
    
• L-fucose/H+ symporter
  • 3o7q – EcSymp
    
  • 3o7p – EcSymp (mutant)
    
• Succinate-acetate/H+ symporter
  • 5zug – EcSymp
    
• Lactose/H+ symporter
  • 1pv6 – EcSymp (mutant)
    
  • 1pv7, 4oaa – EcSymp (mutant) + thiodigalactoside
    
• Glucose/Na+ symporter
  • 7sl8, 7sla – hSymp 1 + nanobody – Cryo EM
    
  • 7vsi – hSymp 2 + PDZK1-interacting protein + drug
    
  • 2xq2 – VpSymp (mutant) – Vibrio parahaemolyticus
    
  • 3dh4 – VpSymp + galactose
    
  • 4m64 – Symp (mutant) - Salmonella typhimurium
    
• Citrate/Na+ symporter
  • 7jsj , 7jsk – hSymp – Cryo EM
    
  • 5a1s – Symp + citrate + Na – Salmonella enterica
    
  • 5x9r, 5xas, 5xat – KpSymp + citrate + Na – Klebsiella pneumoniae
    
  • 4bpq, 5xar – KpSymp
    
• Sodium/alanine symporter
  • 6csf, 6cse – Symp + antibody + Ala – Methanococcus maripaludis
    
• Sodium/aspartate symporter or Glt
  • 6bat – PhSymp + Asp – Pyrococcus horikoshii
    
  • 6wyk, 6wyl – PhSymp (mutant) + Asp – Cryo EM
    
  • 7ahk – PhSymp + Na
    
  • 6uwl, 6uwf, 7ugd, 7ugx, 7uh3, 7uh6 – PhSymp + Asp + Na – Cryo EM
    
  • 6ctf, 6x01 – PhSymp (mutant) + Asp + Na
    
  • 7rcp, 7ugv – PhSymp (mutant) + Asp + Na – Cryo EM
    
  • 6wzb – PhSymp (mutant) + Asp + Na + Hg
    
  • 7ug0 7ugj – PhSymp (mutant) + Asp derivative + Na – Cryo EM
    
  • 6bav, 6bau – PhSymp (mutant) + cysteine derivative
    
  • 6bmi – PhSymp (mutant) + Ser
    
• Sodium/glutamate symporter
  • 4p6h, 4p3j, 4p1a, 3v8g, 3v8f – PhSymp
    
• Neurotransmitter/leucine or Neurotransmitter/Na+ symporter LeuT
  • 5jaf, 5jae, 6xwm, 7dii, 7dix – AaSymp - Aquifex aeolicus
    
  • 5jag – AaSymp (mutant)
    
  • 3gjd – AaSymp + Na
    
  • 3f48, 7lqj – AaSymp + Ala + Na
    
  • 3tu0, 7lqk, 7lql – AaSymp (mutant) + Ala + Na
    
  • 3f4j – AaSymp + glycine + Na
    
  • 2a65, 3f3e, 3usg, 3usi, 3usj, 3usk, 6nle, 8ft4, 8ft5 – AaSymp + Leu + Na
    
  • 3mpn, 3mpq, 3gjc, 4hmk, 4hod, 4fxz, 7dj1, 7dj2, 7djc,– AaSymp (mutant) + leucine + Na
    
  • 3qs4, 3qs5, 3qs6 – AaSymp (mutant) + Trp + Na
    
  • 3f3c – AaSymp + Phe + Na
    
  • 3f3d, 3f4i, 3usl, 3usm, 3uso – AaSymp + Met derivative + Na
    
  • 4fy0 – AaSymp (mutant) + Met + Na
    
  • 2qei – AaSymp + alaine + clomipramine + Na
    
  • 3gwu – AaSymp + sertraline + Na
    
  • 3gwv, 3gww, 2qb4, 2q6h, 2q72, 2qju – AaSymp + drug + Na
    
  • 4mm4 – AaSymp (mutant) + drug + Na
    
  • 3usp – AaSymp + glucoside derivative + Na
    
  • 3tt1, 3tt3 – AaSymp (mutant) + antibody + Na
    
• Divalent ion/Na+ symporter
  • 5ul7, 5ul9, 5uld, 5ule, 4f35 – Symp + Na – Vibrio cholerae
    
• Purine/H+ symporter
  • 5i6c – Symp + xanthine – Aspergillus nidulans
    
• Glutamate/H+ symporter
  • 5dwy, 4ky0 – TkSymp – Thermococcus kodakarensis
    
  • 6xwr – TkSymp – Cryo EM
    
  • 5e9s, 6r7r – TkSymp + Asp
    
  • 8afa – TkSymp (mutant) + Asp – Cryo EMBR />
  • 6zgb, 6zl4, 6zlh – TkSymp + photo switchable compound
    
  • 6xwp, 6xwo, 6xwq – TkSymp + Asp – Cryo EM
    
  • 7ngh – TkSymp + sybody + Asp – Cryo EM
    
  • 6xwn – TkSymp + inhibitor – Cryo EM
    
  • 4oyf – PhSymp
    
  • 2nwl – PhSymp (mutant) + Asp
    
• Glycine/betaine symporter
  • 4llh, 3p03, 4c7r, 4doj – CgSymp (mutant) – Corynebacterium glutamicum
    
  • 4ain – CgSymp + trimethylglycine
    
• Sugar/H+ symporter
  • 8bb6 – AtSymp 1 – Arabidopsis thaliana
    
  • 7aaq, 7aar – AtSymp 10 + antibody + alanine
    
• K+/H+ symporter
  • 8b70 – BsSymp + K – Bacillus subtilis – Cryo EM
    
  • 8b71 – BsSymp + cAMP – Cryo EM
    
• K+/chloride symporter
  • 7d10, 7d8z, 7d90, 7ngb – hSymp – Cryo EM
    
  • 6y5r, 6y5v, 7ain, 7aio – hSymp (mutant) – Cryo EM
    
  • 6kkr, 6kku – hSymp + Cl – Cryo EM
    
  • 6m1y, 6m22, 6m23, 6ukn, 7d99 – hSymp + K + Cl – Cryo EM
    
  • 7aip, 7aiq, 7air – hSymp + ATP – Cryo EM
    
  • 7d14 – mSymp – Cryo EM
    
  • 6kkt – mSymp + K + Cl – Cryo EM
    
  • 6vw9, 6vwa – Symp – Caenorhabditis elegans
    
• Na+/K+/Cl symporter or NKCC1 or solute carrier family 12 member 2
  • 6pzt, 7s1z – hSymp (mutant) - Cryo EM
    
  • 7mxo – hSymp + K + Cl - Cryo EM
    
  • 7s1y – hSymp (mutant) + K + Cl - Cryo EM
    
  • 7s1x – hSymp (mutant) + K + Cl + drug - Cryo EM
    
  • 8fht – hSymp (mutant) + Na + Cl - Cryo EM
    
  • 7n3n, 7sfl – hSymp + furosemide - Cryo EM
    
  • 7smp – hSymp + K + inhibitor - Cryo EM
    
  • 8fhq – hSymp (mutant) + Na + inhibitor - Cryo EM
    
  • 8fhn – hSymp (mutant) + ATP + inhibitor - Cryo EM
    
  • 8fho – hSymp (mutant) + Na + ATP + inhibitor - Cryo EM
    
  • 7zgo – hSymp + Na + K + Cl + cholesterol derivative - Cryo EM
    
  • 6npj – zfSymp – zebrafish - Cryo EM
    
  • 6npk – zfSymp TM domain - Cryo EM
    
  • 6nph – zfSymp TM domain + K + Cl - Cryo EM
    
  • 6npl – zfSymp + K + Cl - Cryo EM
    
  • 3g40 – Symp – Methanosarcina acetivorans
    
• Na+/iodide symporter
  • 7uuv – rSymp (mutant) – rat - Cryo EM
    
  • 7uuz – rSymp (mutant) + Na + perrhenate - Cryo EM
    
  • 7uv0 – rSymp (mutant) + Na + I - Cryo EM
    
• Na+/bicarbonate symporter
  • 6caa – hSymp – Cryo EM
    
• Na+/monocarboxylate symporter
  • 7sl9 – hSymp + nanobody – Cryo EM
    
• Na+/anion symporter
  • 6wtw, 6wu1, 6wu2, 6wu4 – Symp – Lactobacillus acidophilus - Cryo EM
    
  • 6wtx – VcSymp
    
  • 6ww5 – VcSymp + antibody – Cryo EM