Crystal structure of a substrate-free glutamate transporter homologue from Thermococcus kodakarensisCrystal structure of a substrate-free glutamate transporter homologue from Thermococcus kodakarensis

Structural highlights

4ky0 is a 3 chain structure with sequence from Thermococcus kodakarensis KOD1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q5JID0_THEKO

Publication Abstract from PubMed

Archaeal glutamate transporter homologs catalyze the coupled uptake of aspartate and three sodium ions. After the delivery of the substrate and sodium ions to the cytoplasm, the empty binding site must reorient to the outward-facing conformation to reset the transporter. Here, we report a crystal structure of the substrate-free transporter GltTk from Thermococcus kodakarensis, which provides insight into the mechanism of this essential step in the translocation cycle.

Crystal structure of a substrate-free aspartate transporter.,Jensen S, Guskov A, Rempel S, Hanelt I, Slotboom DJ Nat Struct Mol Biol. 2013 Oct;20(10):1224-6. doi: 10.1038/nsmb.2663. Epub 2013, Sep 8. PMID:24013209[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. Jensen S, Guskov A, Rempel S, Hanelt I, Slotboom DJ. Crystal structure of a substrate-free aspartate transporter. Nat Struct Mol Biol. 2013 Oct;20(10):1224-6. doi: 10.1038/nsmb.2663. Epub 2013, Sep 8. PMID:24013209 doi:http://dx.doi.org/10.1038/nsmb.2663

4ky0, resolution 3.00Å

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