Tumor necrosis factor receptor: Difference between revisions

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<StructureSection load='2q1m' size='340' side='right' caption='Structure of human TNFRSF-18 extracellular domain (PDB code [[2q1m]]).' scene=''>
<StructureSection load='1ext' size='350' side='right' caption='Structure of human TNFR extracellular domain complex with sulfate and Mg+2 ion (green) (PDB code [[1ext]]).' scene='' pspeed='8'>
 
__TOC__
== Function ==
== Function ==


'''Tumor necrosis factor receptor''' (TNFR) or '''death receptor''' is  a trimeric cytokine receptor which binds TNF.  TNFR family contains several members and superfamily (TNFRSF) members.  The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains. TNFRSF 6 is called '''Fas'''; TNFRSF 10B is called '''Dr5'''; TNFRSF 21 is called '''Dr6'''; TNFRSF 11A is called '''RANK'''; TNFRSF 18 is called '''GITRL'''.
'''Tumor necrosis factor receptor''' (TNFR) or '''death receptor''' is  a trimeric cytokine receptor which binds TNF<ref>PMID:10358762</ref>.  TNFR family contains several members and superfamily ('''TNFRSF''') members.  <br />
*  '''TNFRSF 1''' is called '''Lymphotoxin-α or TNF-β'''<ref>PMID:20566898</ref>;<br />
*  '''TNFRSF 3''' is called '''TNFR-III''';<br />
*  '''TNFRSF 4''' is called '''OX40L receptor''';<br />
*  '''TNFRSF 5''' is called '''CD40L receptor''';<br />
* '''TNFRSF 6''' is called '''Fas''';<br />
*  '''TNFRSF 9''' is called '''4-1BBL''';<br />
* '''TNFRSF 10''' see [[TRAIL]];<br />
* '''TNFRSF 10B''' is called '''Dr5''';<br />
*  '''TNFRSF 11A''' is called '''RANK''';<br />
*  '''TNFRSF 11B''' is called '''Osteoprotegerin''';<br />
*  '''TNFRSF 12''' is called '''TWEAK''';<br />
*  '''TNFRSF 12A''' is called '''TWEAKR''';<br />
*  '''TNFRSF 13B''' is called '''BAFF or sTALL-1''';<br />
*  '''TNFRSF 13C''' is called '''BAFF receptor''';<br />
*  '''TNFRSF 14''' is called '''LIGHT''';<br />
* '''TNFRSF 16''' is called '''Low-affinity nerve growth factor receptor; p75NTR; p75 neurotrophin receptor''';<br />
* '''TNFRSF 18''' is called '''GITRL''';<br />
* '''TNFRSF 21''' is called '''Dr6''';<br />
* '''TNFRSF 25''' is called '''Dr3''';<br />


== Disease ==
See also
*[[Tumor necrosis factor ligand superfamily]]
*[[Cytokine receptors]]
*[[Receptor]]
*[[Immune receptors]]


== Relevance ==
== Relevance ==
TRAPS - a condition characterized by recurrent episodes of fever is associated with TNFR<ref>PMID:24609716</ref>.


== Structural highlights ==
== Structural highlights ==
 
The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains (CRD). The <scene name='59/590824/Cv/8'>CRD domains are ca. 40 amino-acid long and contain 4-6 cysteine residues</scene>. The CRDs are involved in binding of TNF<ref>PMID:8939750</ref>. <scene name='59/590824/Cv/9'>Mg coordination site</scene>. Water molecules are shown as red spheres.
==3D structures of tumor necrosis factor receptor==
==3D structures of tumor necrosis factor receptor==
[[Tumor necrosis factor receptor 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
 
'''TNFR-1'''
 
[[1ncf]] – hTNFR-1 residues 12-172 (mutant) – human<br />
[[1ich]] – hTNFR-1 death domain (mutant) - NMR<br />
[[2eqp]] – hTNFR-1 residues 28-70 – NMR <br />
[[1ext]] – hTNFR-1 extracellular domain <br />
[[1ft4]] – hTNFR-1 extracellular domain + inhibitor<br />
[[3on9]] – evTNFR SECRET domain – ectromelia virus<br />
[[3ona]] – evTNFR SECRET domain + CX3CL1 <br />
 
'''TNFRSF-1B'''
 
[[3alq]] – hTNFRSF-1B extracellular domain + TNF<br />
 
'''TNFRSF-6 (Fas)'''
 
[[3thm]], [[3tje]] – hTNFRSF-6 extracellular domain + antibody<br />
[[3ezq]] – hTNFRSF-6 Fas DD domain + FADD<br />
[[3oq9]] – mTNFRSF-6 Fas DD domain + FADD - mouse<br />
 
'''TNFRSF-6B'''
 
[[3mhd]] – hTNFRSF-6B extracellular domain <br />
[[4msv]] – hTNFRSF-6B extracellular domain + hTNFRSF-6 extracellular domain<br />
[[4kgg]], [[4kgq]], [[4j6g]] – hTNFRSF-6B extracellular domain + hTNFRSF-14 extracellular domain<br />
[[3mi8]] – hTNFRSF-6B extracellular domain + hTNFRSF-15 extracellular domain<br />
[[3k51]] – hTNFRSF-6B cysteine-rich domain + hTNFRSF-15 extracellular domain<br />
 
'''TNFRSF-10B (Dr5)'''
 
[[2h9g]], [[4od2]], [[1za3]] – hTNFRSF-10B extracellular domain + antibody<br />
[[1d0g]] – hTNFRSF-10B extracellular domain + apoptosis-2 ligand<br />
[[1d4v]] – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand<br />
 
'''TNFRSF-11A (RANK)'''
 
[[3me4]] – mTNFRSF-11A extracellular domain <br />
[[4giq]], [[3qbq]], [[3me2]] – mTNFRSF-11A extracellular domain + RANKL <br />
 
'''TNFRSF-12A'''
 
[[2rpj]] – hTNFRSF-12A cysteine-rich domain – NMR <br />
 
'''TNFRSF-18 (GITRL)'''
 
[[4db5]] – TNFRSF-18 – rabbit <br />
[[4e4s]] – TNFRSF-18 – pika <br />
[[4g4f]] – TNFRSF-18 – bushbaby <br />
[[3fc0]], [[2qdn]], [[3b9i]] – mTNFRSF-18  <br />
[[2q1m]] – hTNFRSF-18 extracellular domain  <br />
[[2r30]], [[2r32]] – hTNFRSF-18 extracellular domain (mutant) <br />
 
'''TNFRSF-21 (Dr6)'''
 
[[3u3p]], [[3u3q]], [[3u3s]], [[3u3t]], [[3u3v]] – hTNFRSF-21 cysteine-rich domain<br />
[[2dbh]] – hTNFRSF-21 CARD-like domain - NMR<br />
[[3qo4]] – hTNFRSF-21 residues 42-218<br />
 
 
 
 


== References ==
== References ==

Latest revision as of 11:53, 20 August 2024

Function

Tumor necrosis factor receptor (TNFR) or death receptor is a trimeric cytokine receptor which binds TNF[1]. TNFR family contains several members and superfamily (TNFRSF) members.

  • TNFRSF 1 is called Lymphotoxin-α or TNF-β[2];
  • TNFRSF 3 is called TNFR-III;
  • TNFRSF 4 is called OX40L receptor;
  • TNFRSF 5 is called CD40L receptor;
  • TNFRSF 6 is called Fas;
  • TNFRSF 9 is called 4-1BBL;
  • TNFRSF 10 see TRAIL;
  • TNFRSF 10B is called Dr5;
  • TNFRSF 11A is called RANK;
  • TNFRSF 11B is called Osteoprotegerin;
  • TNFRSF 12 is called TWEAK;
  • TNFRSF 12A is called TWEAKR;
  • TNFRSF 13B is called BAFF or sTALL-1;
  • TNFRSF 13C is called BAFF receptor;
  • TNFRSF 14 is called LIGHT;
  • TNFRSF 16 is called Low-affinity nerve growth factor receptor; p75NTR; p75 neurotrophin receptor;
  • TNFRSF 18 is called GITRL;
  • TNFRSF 21 is called Dr6;
  • TNFRSF 25 is called Dr3;

See also

Relevance

TRAPS - a condition characterized by recurrent episodes of fever is associated with TNFR[3].

Structural highlights

The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains (CRD). The . The CRDs are involved in binding of TNF[4]. . Water molecules are shown as red spheres.

3D structures of tumor necrosis factor receptor

Tumor necrosis factor receptor 3D structures


Structure of human TNFR extracellular domain complex with sulfate and Mg+2 ion (green) (PDB code 1ext).

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol. 1999;17:331-67. PMID:10358762 doi:http://dx.doi.org/10.1146/annurev.immunol.17.1.331
  2. ↑ Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH. Lymphotoxin-alpha contributes to lymphangiogenesis. Blood. 2010 Sep 23;116(12):2173-82. PMID:20566898 doi:10.1182/blood-2009-12-256065
  3. ↑ Lopalco G, Rigante D, Vitale A, Frediani B, Iannone F, Cantarini L. Tumor necrosis factor receptor-associated periodic syndrome managed with the couple canakinumab-alendronate. Clin Rheumatol. 2015 Apr;34(4):807-9. doi: 10.1007/s10067-014-2556-8. Epub 2014, Mar 11. PMID:24609716 doi:http://dx.doi.org/10.1007/s10067-014-2556-8
  4. ↑ Naismith JH, Devine TQ, Kohno T, Sprang SR. Structures of the extracellular domain of the type I tumor necrosis factor receptor. Structure. 1996 Nov 15;4(11):1251-62. PMID:8939750

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Michal Harel, Alexander Berchansky
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