TRAIL

Function

TRAIL (TNF-related apoptosis-inducing ligand) or TNF ligand superfamily 10 functions as a ligand in the process of apoptosis^[1]. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see Molecular Playground/TRAIL. TRAIL-R2 is called DR5. (1d0g). .

Disease

TRAIL concentrations are reduced in rheumatoid arthritis^[2].

Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, 1d0g

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3D Structures of TRAIL3D Structures of TRAIL

Updated on 12-January-2023

TRAIL-R2 domains – extracellular 54-184; transmembrane 208-242

1d0g, 1d4v, 1du3, 5cir - hTRAIL 114-281 + TRAIL-R2 extracellular domain - human
4n90 - hTRAIL 114-281 + hTRAIL-R2 extracellular domain + antibody
1dg6 – hTRAIL jelly-roll domain 91-281
1d2q - hTRAIL 114-281
4i9x – hTRAIL-R2 extracellular domain + UL141
3x3f, 1za3, 4od2, 2h9g, 6t3j – hTRAIL-R2 extracellular domain + antibody
6nhw – hTRAIL-R2 transmembrane domain - NMR
6nhy – hTRAIL-R2 transmembrane domain (mutant) - NMR

ReferencesReferences

↑ Daniels RA, Turley H, Kimberley FC, Liu XS, Mongkolsapaya J, Ch'En P, Xu XN, Jin BQ, Pezzella F, Screaton GR. Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res. 2005 Jun;15(6):430-8. PMID:15987601 doi:http://dx.doi.org/10.1038/sj.cr.7290311
↑ Dessein PH, Lopez-Mejias R, Ubilla B, Genre F, Corrales A, Hernandez JL, Ferraz-Amaro I, Tsang L, Pina T, Llorca J, Blanco R, Gonzalez-Juanatey C, Gonzalez-Gay MA. TNF-related apoptosis-inducing ligand and cardiovascular disease in rheumatoid arthritis. Clin Exp Rheumatol. 2015 Jul-Aug;33(4):491-7. Epub 2015 May 11. PMID:25962765

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Michal Harel, Alexander Berchansky

[1] Daniels RA, Turley H, Kimberley FC, Liu XS, Mongkolsapaya J, Ch'En P, Xu XN, Jin BQ, Pezzella F, Screaton GR. Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res. 2005 Jun;15(6):430-8. PMID:15987601 doi:http://dx.doi.org/10.1038/sj.cr.7290311

[2] Dessein PH, Lopez-Mejias R, Ubilla B, Genre F, Corrales A, Hernandez JL, Ferraz-Amaro I, Tsang L, Pina T, Llorca J, Blanco R, Gonzalez-Juanatey C, Gonzalez-Gay MA. TNF-related apoptosis-inducing ligand and cardiovascular disease in rheumatoid arthritis. Clin Exp Rheumatol. 2015 Jul-Aug;33(4):491-7. Epub 2015 May 11. PMID:25962765

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