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==Structure of the cargo bound AP-1:Arf1:tetherin-Nef stable closed trimer== | |||
<SX load='6cri' size='340' side='right' viewer='molstar' caption='[[6cri]], [[Resolution|resolution]] 6.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cri]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CRI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cri OCA], [https://pdbe.org/6cri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cri RCSB], [https://www.ebi.ac.uk/pdbsum/6cri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cri ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AP1M1_MOUSE AP1M1_MOUSE] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. | |||
==See Also== | |||
*[[Adaptin 3D structures|Adaptin 3D structures]] | |||
*[[Protein Nef 3D structures|Protein Nef 3D structures]] | |||
[[Category: | *[[Tetherin|Tetherin]] | ||
__TOC__ | |||
</SX> | |||
[[Category: Homo sapiens]] | |||
[[Category: Human immunodeficiency virus 1]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Buffalo CZ]] | |||
[[Category: Hurley JH]] | |||
[[Category: Morris KL]] |
Latest revision as of 17:29, 13 March 2024
Structure of the cargo bound AP-1:Arf1:tetherin-Nef stable closed trimerStructure of the cargo bound AP-1:Arf1:tetherin-Nef stable closed trimer
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