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==Structure of the PDlim2 PDZ domain in complex with the C-terminal 6-peptide extension of NS1== | |||
<StructureSection load='3pdv' size='340' side='right'caption='[[3pdv]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3pdv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/chicken/Henan/12/2004(H5N1)) Influenza A virus (A/chicken/Henan/12/2004(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PDV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pdv OCA], [https://pdbe.org/3pdv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pdv RCSB], [https://www.ebi.ac.uk/pdbsum/3pdv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pdv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDLI2_HUMAN PDLI2_HUMAN] Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. | |||
==See Also== | |||
*[[PDZ and LIM domain protein|PDZ and LIM domain protein]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Li X]] | |||
Latest revision as of 16:30, 1 March 2024
Structure of the PDlim2 PDZ domain in complex with the C-terminal 6-peptide extension of NS1Structure of the PDlim2 PDZ domain in complex with the C-terminal 6-peptide extension of NS1
Structural highlights
FunctionPDLI2_HUMAN Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. See Also |
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