PDZ and LIM domain protein

Function PDZ and LIM domain proteins (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure. For details on PDLIM see Group:MUZIC:ZASP and Group:MUZIC:Enigma Family. PDLIM1 promotes cell attachment at the cytoskeleton. For details see Group:MUZIC:ALP. PDLIM2 may have a role in bringing proteins to the cytoskeleton. PDLIM3 may have a role in organizing actin filament arrays within muscle cells. PDLIM4 is a Zn+2 ion binding protein. PDLIM5 has important role in heart development by scaffolding PKC to the Z-disk region. PDLIM7 is an adaptor protein localizing the LIM-binding proteins to muscle tissues. Relevance PDLIM2 may contribute to cancer cells migratory capacity. PDLIM5 overexpression promotes the development of heart hypertrophy.

spinqualitylabelsall models Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry 2pa1) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of PDZ and LIM domain protein3D structures of PDZ and LIM domain protein

Updated on 21-August-2023

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• PDLIM1
  • 2pkt – hPDLIM + α-actinin C terminal - human
    
  • 1x62 – hPDLIM LIM domain - NMR
    
• PDLIM2
  • 1vb7 – mPDLIM PDZ domain – mouse - NMR
    
  • 2pa1 – hPDLIM PDZ domain + β-tropomysin C terminal
    
  • 3pdv – hPDLIM PDZ domain + influenza virus NS1 C terminal
    
• PDLIM3
  • 1v5l – mPDLIM PDZ domain - NMR
    
  • 1x64 – mPDLIM LIM domain - NMR
    
  • 4ydp - hPDLIM PDZ domain
    
• PDLIM4
  • 4q2o – hPDLIM
    
  • 2v1w – hPDLIM + α-actinin C terminal
    
  • 2eeg – hPDLIM PDZ domain - NMR
    
• PDLIM5
  • 1wf7 – mEnigma homolog protein PDZ domain - NMR
    
  • 2dar – hEnigma homolog protein LIM domain - NMR
    
  • 2uzc – hPDLIM + α-actinin C terminal
    
• PDLIM7
  • 2q3g – hPDLIM PDZ domain + β-tropomysin C terminal
    
  • 7rm8 – hPDLIM PDZ domain + SNX17 peptide - NMR
    
• PDLIM
  • 1rgw – hPDLIM PDZ domain - NMR