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==Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Indole Aza-SAM== | |||
<StructureSection load='4gon' size='340' side='right'caption='[[4gon]], [[Resolution|resolution]] 2.72Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4gon]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GON FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Y1:5-{[(3S)-3-AMINO-3-CARBOXYPROPYL][2-(1H-INDOL-3-YL)ETHYL]AMINO}-5-DEOXYADENOSINE'>0Y1</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gon OCA], [https://pdbe.org/4gon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gon RCSB], [https://www.ebi.ac.uk/pdbsum/4gon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gon ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DMA_ECOLI DMA_ECOLI] Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication. | |||
==See Also== | |||
*[[DNA adenine methylase|DNA adenine methylase]] | |||
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Harmer JE]] | |||
[[Category: Roach PL]] | |||
Latest revision as of 14:33, 1 March 2024
Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Indole Aza-SAMCrystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Indole Aza-SAM
Structural highlights
FunctionDMA_ECOLI Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication. See Also |
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