Integrin 3D structures: Difference between revisions

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New page: ==3D structures of integrin== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *IG CR3 **1ido – hIG I domain ...
 
Michal Harel (talk | contribs)
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**[[1ido]] – hIG I domain + Mg – human<br />
**[[1ido]] – hIG I domain + Mg – human<br />
**[[1jlm]] - hIG I domain + Mn<br />
**[[1jlm]] - hIG I domain + Mn<br />
*IG CD11a or IG α-L
**[[1lfa]] - hIG I domain + Mn<br />
**[[1zon]] - hIG I domain<br />
**[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg<br />
**[[1mq9]] - hIG I domain (mutant) + Mn<br />
**[[1mjn]] - hIG I domain (mutant) + Mg<br />
**[[1mqa]] - hIG I domain (mutant) <br />
**[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR<BR />
*''IG CD11a complexes''
**[[1cqp]] - hIG I domain + lovastatin + Mg<br />
**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg<br />
**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
**[[1xdd]], [[1xdg]], [[1xuo]] - hIG I domain + inhibitor + Mg<br />
**[[4ixd]] - hIG I domain + activator + Mg<br />
**[[3f78]] - hIG I domain + anesthetic + Mg<br />
**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
*IG CD11b
**[[1bho]] - hIG I domain + Mg<br />
**[[1bhq]] - hIG I domain + Cd<br />
**[[1m1u]] - hIG I domain (mutant) + Ca<br />
**[[1n9z]] - hIG I domain (mutant) + Mg<br />
**[[1idn]], [[1na5]] - hIG I domain<br />
**[[1mf7]] - hIG I domain (mutant)
*IG CD11c
**[[1n3y]] - hIG I domain (mutant)


*IG α-1 (CD49a)
*IG α-1 (CD49a)


**[[1ck4]] - rIG I domain – rat<br />
**[[4a0q]] - hIG I domain (mutant) + Mg<br />
**[[4a0q]] - hIG I domain (mutant) + Mg<br />
**[[2l8s]] - hIG transmembrane domain – NMR<BR />
**[[2l8s]] - hIG transmembrane domain – NMR<BR />
**[[5hgj]] - hIG VWFA domain<br />
**[[5hgj]] - hIG VWFA domain<br />
**[[2m32]] - hIG I domain + collagen peptide<br />
**[[1ck4]] - rIG I domain – rat<br />
**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />
**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />
**[[2m32]] - hIG I domain + collagen peptide<br />


*IG α-2 (CD49b)
*IG α-2 (CD49b)
Line 66: Line 30:
**[[2k1a]] - hIG transmembrane domain – NMR<BR />
**[[2k1a]] - hIG transmembrane domain – NMR<BR />


*IG α-1 β-1 (CD49a-CD49b)
*IG α-1 + IG β-1 (CD49a-CD49b)


**[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br />
**[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br />
**[[1pt6]] - hIG I domain + Mg<br />
**[[1pt6]] - hIG I domain + Mg<br />


*IG α-2 (CD49b) β
*IG α-2 (CD49b) + IG β


**[[5hj2]] - hIG I domain<br />
**[[5hj2]] - hIG I domain<br />
Line 77: Line 41:
**[[2k1a]] - hIG transmembrane domain – NMR<br />
**[[2k1a]] - hIG transmembrane domain – NMR<br />


*IG α-2b β-3 (CD61)
*IG α-2b + IG β-3 (CD61)


**[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
**[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
**[[1m8o]] - hIG cytoplasmic domain – NMR<BR />
**[[1m8o]] - hIG cytoplasmic domain – NMR<BR />
**[[4cak]] – hIG – Cryo-EM<br />
**[[4cak]] – hIG – Cryo-EM<br />
**[[2k9j]], [[2knc]] - hIG transmembrane domain – NMR<BR />
**[[2k9j]], [[2knc]], [[7kn0]] - hIG transmembrane domain – NMR<BR />
**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />
**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />
**[[3fc3]] – hIG (mutant) + Mg<br />
**[[3fc3]] – hIG (mutant) + Mg<br />
Line 89: Line 53:
**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />
**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
**[[6v4p]], [[7la4]] – hIG + antibody – Cryo-EM<br />
**[[7l8p]], [[7tct]], [[7td8]], [[7tho]], [[7tmz]], [[7tpd]], [[7u60]], [[7u9f]], [[7u9v]], [[7ubr]], [[7ucy]], [[7udg]], [[7udh]], [[7ue0]], [[7ufh]], [[7uh8]], [[7uje]], [[7ujk]], [[7uk9]], [[7uko]], [[7ukp]], [[7ukt]] – hIG + antibody + drug<br />


*IG α-4
*IG α-4
Line 94: Line 60:
**[[4irz]] - hIG + antibody <br />
**[[4irz]] - hIG + antibody <br />


*IG α-4 (CD49d) β-7
*IG α-4 (CD49d) + IG β-7


**[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br />
**[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br />
**[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br />
**[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br />


*IG α-5 (CD49e) β-1 (CD29)
*IG α-5 (CD49e) + IG β-1 (CD29)


**[[7nxd]] – hIG + Mg – Cryo-EM<br />
**[[7nwl]] – hIG + fibronectin + laminin – Cryo-EM<br />
**[[4wjk]] - hIG headpiece (mutant) + Mg<br />
**[[4wjk]] - hIG headpiece (mutant) + Mg<br />
**[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br />
**[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br />
Line 106: Line 74:
**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />


*IG α-5 (CD49e) β-3 (CD61) ectodomain
*IG α-5 (CD49e) + IG β-3 (CD61) ectodomain


**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />
**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />
Line 114: Line 82:
**[[1l5g]] - hIG + tripeptide + Mn<br />
**[[1l5g]] - hIG + tripeptide + Mn<br />


*IG α-5 β-6
*IG α-5 + IG β-6


**[[4um8]] – hIG headpiece (mutant) + Ni<br />
**[[4um8]] – hIG headpiece (mutant) + Ni<br />
Line 121: Line 89:
**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
**[[5ffo]] – hIG headpiece + TGF-beta-1<br />
**[[5ffo]] – hIG headpiece + TGF-beta-1<br />
*IG α-6 + IG β-1
**[[7ceb]], [[7cec]] – hIG headpiece + laminin + Mg<br />


*IG α-L
*IG α-L


**[[4ixd]] – hIG I domain<br />
**[[1lfa]] - hIG I domain + Mn <br />
**[[1zon]], [[4ixd]], [[7kc3]] - hIG I domain 153-334 <br />
**[[1mqa]] - hIG I domain (mutant) <br />
**[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg <br />
**[[1mq9]] - hIG I domain (mutant) + Mn <br />
**[[1mjn]] - hIG I domain (mutant) + Mg <br />
**[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR <br />
**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br />
**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br />
**[[2m3e]] – hIG transmembrane domain - NMR<br />
**[[2m3e]] – hIG transmembrane domain - NMR<br />


*IG α-L β-2
*IG α-L complexes
 
**[[1cqp]] - hIG I domain + lovastatin + Mg <br />
**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg <br />
**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
**[[1xdd]], [[1xdg]], [[1xuo]], [[7kc5]] - hIG I domain + inhibitor + Mg<br />
**[[7kc6]] - hIG I domain + drug + Mg<br />
**[[3f78]] - hIG I domain + anesthetic + Mg<br />
**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
 
*IG α-L + IG β-2


**[[5e6u]] – hIG headpiece (mutant) + Ni<br />
**[[5e6u]] – hIG headpiece (mutant) + Ni<br />
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*IG α-M
*IG α-M


**[[1idn]], [[1na5]] - hIG<br />
**[[1mf7]] - hIG (mutant) <br />
**[[1bho]] - hIG + Mg<br />
**[[1bhq]] - hIG + Cd<br />
**[[1m1u]] - hIG (mutant) + Ca<br />
**[[1n9z]] - hIG (mutant) + Mg<br />
**[[3q3g]], [[3qa3]] – hIG + antibody<br />
**[[3q3g]], [[3qa3]] – hIG + antibody<br />
**[[4m76]] – hIG + complement C3<br />
**[[4m76]] – hIG + complement C3<br />
**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />
**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<br />
**[[4xw2]] – hIG + simvastatin<br />
**[[4xw2]] – hIG + simvastatin<br />
**[[6rhv]], [[6rhw]] – hIG + cytolysin<br />
*IG α-M + IG β-2
**[[7usm]] – hIG ectodomain – Cryo EM<br />
**[[7usl]] – hIG ectodomain + adenylate cyclase toxin + antibody – Cryo EM<br />
**[[7p2d]] – hIG ectodomain + nanobody <br />
*IG α-V + IG β-3
**[[6mk0]] – hIG + antagonist<br />
**[[6msl]] – hIG + cysteine knot protein<br />
**[[6msu]] – hIG + EETI-II<br />
**[[6naj]] – hIG + fibronectin<br />


*IG α-V β-8
*IG α-V + IG β-8


**[[6djp]] – hIG + antibody – Cryo EM<br />
**[[6djp]], [[6ujb]], [[6ujc]] – hIG + antibody – Cryo EM<br />
**[[6om1]] – hIG (mutant)<br />
**[[6om2]] – hIG (mutant) + Protgf-b1 RGD peptide<br />
**[[6uja]] – hIG + Protgf-b1 RGD – Cryo EM<br />
**[[7y1t]] – hIG + TGF-b1 – Cryo EM<br />


*IG α-X
*IG α-X


**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
**[[1n3y]] – hIG domain I (mutant)<br />


*IG α-X β-2 (CD18)
*IG α-X + IG β-2 (CD18)


**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
Line 169: Line 184:
**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
**[[6bxb]], [[6bxf]] – hIG/hIG α-L <br />


*IG β-4 (CD104; Gp150)
*IG β-4 (CD104; Gp150)

Latest revision as of 11:32, 31 May 2023

3D structures of integrin3D structures of integrin

Updated on 31-May-2023

    • 4irz - hIG + antibody
  • IG α-4 (CD49d) + IG β-7
    • 3v4p - hIG headpiece (mutant) + antibody + Mg
    • 3v4v - hIG headpiece (mutant) + antibody + inhibitor + Mg
  • IG α-5 (CD49e) + IG β-1 (CD29)
    • 7nxd – hIG + Mg – Cryo-EM
    • 7nwl – hIG + fibronectin + laminin – Cryo-EM
    • 4wjk - hIG headpiece (mutant) + Mg
    • 4wk0, 4wk2, 4wk4 - hIG headpiece (mutant) + peptide + Mg
    • 3vi3 - hIG headpiece + antibody + Mg
    • 3vi4 - hIG headpiece + antibody + peptide + Mg
  • IG α-5 (CD49e) + IG β-3 (CD61) ectodomain
  • IG α-5 + IG β-6
    • 4um8 – hIG headpiece (mutant) + Ni
    • 5ffg – hIG headpiece + Ca
    • 4um9 – hIG headpiece (mutant) + Mg + transforming growth factor β 3
    • 5neu, 5net, 5ner, 5nem – hIG headpiece + foot-and-mouth virus – Cryo EM
    • 5ffo – hIG headpiece + TGF-beta-1
  • IG α-6 + IG β-1
    • 7ceb, 7cec – hIG headpiece + laminin + Mg
  • IG α-L
    • 1lfa - hIG I domain + Mn
    • 1zon, 4ixd, 7kc3 - hIG I domain 153-334
    • 1mqa - hIG I domain (mutant)
    • 1zoo, 1zop, 3f74 - hIG I domain + Mg
    • 1mq9 - hIG I domain (mutant) + Mn
    • 1mjn - hIG I domain (mutant) + Mg
    • 2k8o – hIG cytoplasmic domain (mutant) – NMR
    • 5e6s, 5e6r – hIG AI, headpiece,pocket domains + Mg
    • 2m3e – hIG transmembrane domain - NMR
  • IG α-L complexes
    • 1cqp - hIG I domain + lovastatin + Mg
    • 1mq8, 3bn3, 3tcx - hIG I domain (mutant) + intracellular adhesion molecule + Mg
    • 1t0p - hIG I domain + intracellular adhesion molecule-3 + Mg
    • 1rd4, 2ica, 3bqm, 3bqn, 3e2m - hIG I domain + inhibitor
    • 2o7n, 3m6f - hIG I domain + antagonist
    • 1xdd, 1xdg, 1xuo, 7kc5 - hIG I domain + inhibitor + Mg
    • 7kc6 - hIG I domain + drug + Mg
    • 3f78 - hIG I domain + anesthetic + Mg
    • 3eoa, 3eob - hIG I domain + antibody
    • 3hi6 - hIG I domain (mutant) + antibody + Mn
  • IG α-L + IG β-2
    • 5e6u – hIG headpiece (mutant) + Ni
  • IG α-M
  • IG α-M + IG β-2
    • 7usm – hIG ectodomain – Cryo EM
    • 7usl – hIG ectodomain + adenylate cyclase toxin + antibody – Cryo EM
    • 7p2d – hIG ectodomain + nanobody
  • IG α-V + IG β-3
    • 6mk0 – hIG + antagonist
    • 6msl – hIG + cysteine knot protein
    • 6msu – hIG + EETI-II
    • 6naj – hIG + fibronectin
  • IG α-V + IG β-8
    • 6djp, 6ujb, 6ujc – hIG + antibody – Cryo EM
    • 6om1 – hIG (mutant)
    • 6om2 – hIG (mutant) + Protgf-b1 RGD peptide
    • 6uja – hIG + Protgf-b1 RGD – Cryo EM
    • 7y1t – hIG + TGF-b1 – Cryo EM
  • IG α-X
    • 2luv – hIG cytoplasmic domain – NMR
    • 1n3y – hIG domain I (mutant)
  • IG α-X + IG β-2 (CD18)
  • IG β-1D
    • 3g9w – hIG cytoplasmic tail + talin 2 F2-F3 domain
  • IG β-2 (CD18)
    • 2p26, 2p28, 5e6w – hIG phe2 + phe3 domains
    • 1yuk – hIG chain A PSI domain + chain B I-EGF domain
    • 5zaz – hIG transmembrane domain - NMR
  • IG β-3 (CD61)
    • 1s4x, 2kv9, 2ljd, 2lje, 2ljf – hIG cytoplasmic domain – NMR
    • 2rmz, 2rn0 – hIG transmembrane domain – NMR
    • 2l91 - hIG transmembrane domain (mutant) – NMR
    • 2l1c – hIG cytoplasmic tail + SHC
    • 2mtp – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain
    • 6bxb, 6bxf – hIG/hIG α-L
  • IG β-4 (CD104; Gp150)
    • 2f7q, 3f7r, 1qg3, 3f7q, 4wtw, 4wtx - hIG fibronectin type III domain
    • 2yrz – hIG fibronectin type III domain – NMR
    • 3f7p, 4q58 - hIG fibronectin type III domain + plectin-1
    • 6gvl - hIG fibronectin type III domain + dystonin
    • 6gvk - hIG fibronectin type III domain (mutant) + dystonin
    • 3fq4, 3fso, 3h6a – hIG Calx-β domain
    • 6hyf - rIG fibronectin type III domain
  • IG β-7
    • 2brq, 2jf1 – hIG cytoplasmic tail + filamin rod domain

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel
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