Histone methyltransferase 3D structures: Difference between revisions

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**[[2igq]] – hHMT-1 C terminal
**[[2igq]] – hHMT-1 C terminal


*Histone-lysine N-methyltransferase; Domains – Tudor 190-410
*Histone-lysine N-methyltransferase; Domains – Tudor 190-410; CxxC or zinc finger 1146-1214


**[[3s8s]] – hKHMT SETD1A RRM domain<br />
**[[3s8s]] – hKHMT SETD1A RRM domain<br />
Line 25: Line 25:
**[[1h3i]] - hKHMT SET7/9 residues 52-344<br />
**[[1h3i]] - hKHMT SET7/9 residues 52-344<br />
**[[2o8j]] - hKHMT H3K9 residues 913-1193<br />
**[[2o8j]] - hKHMT H3K9 residues 913-1193<br />
**[[2j2s]] – Mll1 CxxC domain - NMR<br />
**[[5f5e]] – Mll1 residues 3813-3969<br />
**[[5f5e]] – Mll1 residues 3813-3969<br />
**[[5f59]] – Mll3 residues 4757-4910<br />
**[[5f59]] – Mll3 residues 4757-4910<br />
Line 51: Line 52:
**[[2j8a]] – KHMT SET1 RRM domain – yeast<br />
**[[2j8a]] – KHMT SET1 RRM domain – yeast<br />
**[[1u2z]] – yKHMT C terminal<br />
**[[1u2z]] – yKHMT C terminal<br />
**[[5h6z]], [[5ww0]] - KHMT SET7 – fission yeast <br />
**[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
**[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
**[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
**[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
Line 127: Line 129:
**[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
**[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
**[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br />
**[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br />
**[[6e2h]] – hKHMT SET/Ash2 + DPY-30L <br />
**[[4riq]], [[6e2h]] – hKHMT SET/Ash2 + DPY-30L <br />
**[[6u4y]] - hKHMT Ezh2 + polycomb protein EED<br />
**[[6u4y]] - hKHMT Ezh2 + polycomb protein EED<br />
**[[6jn2]] – hKHMT4 coiled-coil domain 470-550 + AF-10<br />
**[[6jn2]] – hKHMT4 coiled-coil domain 470-550 + AF-10<br />
Line 168: Line 170:
**[[6cen]] - hKHMT Nsd3 + inhibitor peptide + SAM<br />
**[[6cen]] - hKHMT Nsd3 + inhibitor peptide + SAM<br />
**[[7bre]] – hKHMT Mll1 + RBBP5 + Ash2L<br />
**[[7bre]] – hKHMT Mll1 + RBBP5 + Ash2L<br />
**[[5f6l]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br />
**[[5f6l]], [[7w67]], [[7w6a]], [[7w6i]], [[7w6j]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br />
**[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br />
**[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br />
**[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br />
**[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br />
Line 205: Line 207:
**[[7crr]] - hKHMT Nsd3 in nucleosome – Cryo EM<br />
**[[7crr]] - hKHMT Nsd3 in nucleosome – Cryo EM<br />
**[[7crp]], [[7crq]] - hKHMT Nsd3 (mutant) in nucleosome – Cryo EM<br />
**[[7crp]], [[7crq]] - hKHMT Nsd3 (mutant) in nucleosome – Cryo EM<br />
**[[6w5i]], [[6w5m]], [[6w5n]] – hKHMT Ash2L in nucleosome – Cryo EM<br />
**[[7xpx]] – hKHMT SET8 in nucleosome – Cryo EM<br />
**[[7mbm]], [[7mbn]], [[7ud5]] – hKHMT MLL1 in nucleosome – Cryo EM<br />
**[[5t0m]], [[5t0k]] - hKHMT EHMT2 SET domain + SAM + SAH + H3 peptide<br />
**[[5t0m]], [[5t0k]] - hKHMT EHMT2 SET domain + SAM + SAH + H3 peptide<br />
**[[5ls6]], [[5hyn]] - hKHMT Ezh2in+ polycomb complex + inhibitor<br />
**[[5ls6]], [[5hyn]] - hKHMT Ezh2in+ polycomb complex + inhibitor<br />
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**[[6ugh]] – hPRMT5 + MEP50 – Cryo EM<br />
**[[6ugh]] – hPRMT5 + MEP50 – Cryo EM<br />
**[[5egs]], [[5wcf]], [[5lv5]], [[5lv4]], [[5lv3]], [[5lv2]] – hPRMT6 + inhibitor<br />
**[[5egs]], [[5wcf]], [[5lv5]], [[5lv4]], [[5lv3]], [[5lv2]] – hPRMT6 + inhibitor<br />
**[[5dst]] – hPRMT8 catalytic domain + SAH<br />
**[[5ih3]] – mPRMT4 + SAH<br />
**[[5ih3]] – mPRMT4 + SAH<br />
**[[5k8v]], [[5isi]], [[5ish]], [[5isg]], [[5isf]], [[5ise]], [[5isd]], [[5isc]], [[5isb]], [[5isa]], [[5is9]], [[5is8]], [[5is7]], [[5is6]], [[5tbj]], [[5tbi]], [[5tbh]], [[5ntc]], [[5lkj]], [[5k8x]], [[5k8w]] – mPRMT4 + inhibitor<br />
**[[5k8v]], [[5isi]], [[5ish]], [[5isg]], [[5isf]], [[5ise]], [[5isd]], [[5isc]], [[5isb]], [[5isa]], [[5is9]], [[5is8]], [[5is7]], [[5is6]], [[5tbj]], [[5tbi]], [[5tbh]], [[5ntc]], [[5lkj]], [[5k8x]], [[5k8w]] – mPRMT4 + inhibitor<br />
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT4 + poly(A)-binding protein peptide + inhibitor<br />
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT4 + poly(A)-binding protein peptide + inhibitor<br />
**[[4c04]], [[6sq3]], [[6sq4]] – mPRMT6 + inhibitor<br />
**[[4c04]], [[6sq3]], [[6sq4]], [[7nud]], [[7nue]], [[7p2r]], [[7ppq]], [[7ppy]], [[7pu8]], [[7puc]], [[7puq]], [[7pv6]] – mPRMT 6 + inhibitor<br />
**[[6sqk]] – mPRMT 6 + peptide<br />
**[[7os4]] – mPRMT 6 + histone H3.1<br />
**[[7okp]] – mPRMT 6 + histone H3.3<br />
**[[4c05]], [[5fqo]], [[5fqn]] – mPRMT6 + SAH<br />
**[[4c05]], [[5fqo]], [[5fqn]] – mPRMT6 + SAH<br />
**[[4c4a]] – mPRMT7 + SAH<br />
**[[4c4a]] – mPRMT7 + SAH<br />

Latest revision as of 11:21, 22 May 2023

3D Structures of histone methyltransferase3D Structures of histone methyltransferase

Updated on 22-May-2023

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman
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