6pww

Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosomeCryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome

6pww, resolution 4.40Å Show:Asymmetric Unit Biological Assembly Structural highlights 6pww is a 13 chain structure with sequence from Homo sapiens, Xenopus laevis and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.4Å Ligands: Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RBBP5_HUMAN In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. See Also Histone 3D structures Histone methyltransferase 3D structures Retinoblastoma-binding protein 3D structures WD-repeat protein 3D structures