BRCA: Difference between revisions

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<StructureSection load='' size='450' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code [[3coj]]) ' scene='75/750267/Cv/3' pspeed='8'>
<StructureSection load='' size='450' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code [[3coj]]) ' scene='75/750267/Cv/4' pspeed='8'>


== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
The <scene name='75/750267/Cv/1'>phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains</scene>.  These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>. <scene name='75/750267/Cv/2'>Phosphoserine binding</scene>.  
The <scene name='75/750267/Cv/5'>phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains</scene>.  These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>. <scene name='75/750267/Cv/6'>Phosphoserine binding</scene>.  
 
</StructureSection>


==3D structures of BRCA==
==3D structures of BRCA==
[[BRCA 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*BRCA1
 
**[[4ofb]], [[4y18]], [[4y2g]], [[4u4a]], [[4jlu]], [[4ifi]], [[4igk]], [[3k0h]], [[3k0k]], [[3coj]], [[1y98]], [[1t15]], [[1t29]], [[1t2v]] - hBRCA1 BRCT1 domain + peptide inhibitor - human<br />
**[[3pxa]], [[3pxb]], [[3pxc]], [[3pxd]], [[3pxe]], [[3k15]], [[3k16]] - hBRCA1 BRCT1 domain (mutant) + peptide inhibitor<br />
**[[1jnx]] - hBRCA1 BRCT domain<br />
**[[2ing]], [[1t2u]], [[1n5o]] - hBRCA1 BRCT1 domain (mutant)<br />
**[[1oqa]] - hBRCA1 BRCT-C domain - NMR<br />
**[[1l0b]] - BRCA1 BRCT domain - rat<br />
**[[2n9e]] - hBRCA1 SUMO-interacting motif + small ubiquitin-related modifier - NMR<br />
**[[4mkf]], [[4mkg]] - hBRCA1 SUMO-interacting motif - NMR<br />
**[[1jm7]] - hBRCA1 Ring domain + BARD1 ring domian - NMR<br />
 
*BRCA2


**[[1iyj]], [[1miu]] – hBRCA2 residues 2335-3151 + DSS1<br />
**[[1mje]] – hBRCA2 residues 2335-3151 + DSS1 + ssDNA<br />
**[[1n0w]] – hBRCA2 BRC repeat 4 + RAD51 + linker<br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 12:58, 16 April 2019


Function

BRCA1 and BRCA2 or breast cancer type 1 susceptibility protein are tumor suppressors which help repair damaged DNA. For more details see:

Disease

Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers[1].

Structural highlights

The . These domains contain most of the mutations seen in BRCA1[2]. .

3D structures of BRCA

BRCA 3D structures


Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code 3coj)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer PMID:20301425
  2. ↑ Shen Y, Tong L. Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry. 2008 May 27;47(21):5767-73. Epub 2008 May 2. PMID:18452305 doi:10.1021/bi800314m

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
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