BRCA

Function BRCA1 and BRCA2 or breast cancer type 1 susceptibility protein are tumor suppressors which help repair damaged DNA. For more details see: RING Finger Domain of BRCA1 and BARD1 Heterodimer. Mutations in BRCA1/BARD1 RING-domain heterodimer. Mutations in Brca1 BRCT Domains. Disease Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers. Structural highlights The . These domains contain most of the mutations seen in BRCA1. . 3D structures of BRCA BRCA 3D structures

spinqualitylabelsall models Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code 3coj) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image