Cluster of Differentiation CD38: Difference between revisions
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<StructureSection load='2i65' size='450' side='right' scene='42/422415/Cv/3' caption='Human Cluster of Differentiation 38 (CD38) complex with NAD [[2i65]]'> | |||
__TOC__ | |||
== Function == | |||
[[Cluster of Differentiation 38]] (CD38), known also as '''ADP-ribosyl cyclase 1''' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca+2 signaling. '''ADP-ribosyl cyclase''' (ADPRC) is the ''Aplysia californica'' homolog of CD38. It catalyzes the synthesis and hydrolysis of cyclic ADP-ribose. It uses NAD+ as substrate and produces cyclic ADP-ribose (cADPR).<ref>PMID:16154090</ref> | |||
== Relevance == | |||
CD38 is used as a marker for cell activation and for leukemia. | |||
== Structural highlights == | |||
<scene name='42/422415/Cv/4'>CD38 active site contains NAD</scene>.<ref>PMID:16951430</ref> | |||
</StructureSection> | |||
== 3D Structures of Cluster of Differentiation 38 == | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
* CD38 | |||
**[[3gc6]] – bCD38 - bovine<br /> | |||
**[[3gh3]], [[3ghh]] – bCD38 residues 32-278<br /> | |||
**[[2eg9]] - CD38 enzymatic domain (mutant) – mouse<br /> | |||
**[[2ef1]] - hCD38 enzymatic domain – human<br /> | |||
**[[1yh3]] - hCD38 enzymatic domain (mutant)<br /> | |||
**[[1zvm]] - hCD38 (mutant)<br /> | |||
**[[1isf]] – hADPRC2 (mutant) <br /> | |||
* CD38+ligand | |||
**[[3i9m]], [[3i9n]] – hCD38 enzymatic domain+ADPR analog<br /> | |||
**[[3f6y]] – hCD38 enzymatic domain+Ca++<br /> | |||
**[[3dzf]] - hCD38 enzymatic domain+intermediate<br /> | |||
**[[3dzg]] - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex<br /> | |||
**[[3dzh]] - hCD38 enzymatic domain (mutant)+GTP<br /> | |||
**[[3dzi]] - hCD38 enzymatic domain (mutant)+intermediate/GTP complex<br /> | |||
**[[3dzj]], [[3dzk]] - hCD38 enzymatic domain (mutant)+NMN complex<br /> | |||
**[[2pgj]], [[2pgl]] - hCD38 enzymatic domain (mutant)+substrate analog<br /> | |||
**[[2o3t]] - hCD38 enzymatic domain (mutant)+cGDPR<br /> | |||
**[[3u4h]], [[3u4i]] - hCD38 enzymatic domain (mutant)+cIDPR<br /> | |||
**[[2o3u]] - hCD38 enzymatic domain (mutant)+NGD <br /> | |||
**[[2o3q]], [[2o3r]], [[2o3s]] - hCD38 enzymatic domain (mutant)+cADPR<br /> | |||
**[[4f45]] - hCD38 enzymatic domain (mutant)+ NAADP<br /> | |||
**[[4f46]] - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP<br /> | |||
**[[4cmh]] - hCD38 enzymatic domain + antibody<br /> | |||
**[[2i65]] – hCD38+NAD<br /> | |||
**[[3kou]] - hCD38+NAD derivative<br /> | |||
**[[2i67]] - hCD38 (mutant)+ADPR<br /> | |||
**[[2hct]] - hCD38 enzymatic domain (mutant)+NMN<br /> | |||
**[[3ofs]] - hCD38 enzymatic domain (mutant)+ ARA-2 F-ADPR<br /> | |||
**[[3raj]] - hCD38 enzymatic domain (mutant)+ FAB<br /> | |||
**[[3rok]], [[3rom]] - hCD38 (mutant) + arabinitol derivative<br /> | |||
**[[3roq]] - hCD38 (mutant) + hydrofuran derivative<br /> | |||
**[[3rop]] - hCD38 (mutant) + arabinitol derivative + nicotinamide<br /> | |||
**[[3p5s]] - bADPRC + arabinitol derivative<br /> | |||
*ADPRC | |||
**[[1r12]] - AcADPRC - ''Aplysia californica''<br /> | |||
**[[1r0s]] – AcADPRC (mutant) <br /> | |||
*ADPRC+ligand | |||
**[[1r15]] - AcADPRC+nicotinamide<br /> | |||
**[[3i9j]] – AcADPRC+nicotinamide+2F-NAD+2F-ADPRI<br /> | |||
**[[3i9k]] – AcADPRC (mutant)+NAD<br /> | |||
**[[3i9l]] – AcADPRC (mutant)+N1-CIDPR<br /> | |||
**[[3i9o]] – AcADPRC+Ribosyl-2F-ADPR<br /> | |||
**[[3zwx]], [[3zwy]] – AcADPRC + 8-Br-ADPR<br /> | |||
**[[1r16]] - AcADPRC+3-pyridinylcarbinol<br /> | |||
**[[3zwm]] – AcADPRC + NAD + cADPR<br /> | |||
**[[3zwn]] – AcADPRC + NGD + cGDPR<br /> | |||
**[[3zwo]] – AcADPRC + NGD + GDPR<br /> | |||
**[[3zwp]], [[3zwv]], [[3zww]] – AcADPRC+ diphosphate ribosyl ara-2F-ADPR<br /> | |||
}} | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 16:16, 10 July 2018
FunctionCluster of Differentiation 38 (CD38), known also as ADP-ribosyl cyclase 1 (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca+2 signaling. ADP-ribosyl cyclase (ADPRC) is the Aplysia californica homolog of CD38. It catalyzes the synthesis and hydrolysis of cyclic ADP-ribose. It uses NAD+ as substrate and produces cyclic ADP-ribose (cADPR).[1] RelevanceCD38 is used as a marker for cell activation and for leukemia. Structural highlights.[2] |
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3D Structures of Cluster of Differentiation 383D Structures of Cluster of Differentiation 38
Updated on 10-July-2018
ReferencesReferences
- ↑ Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q. Crystal structure of human CD38 extracellular domain. Structure. 2005 Sep;13(9):1331-9. PMID:16154090 doi:http://dx.doi.org/10.1016/j.str.2005.05.012
- ↑ Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q. Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis. J Biol Chem. 2006 Oct 27;281(43):32861-9. Epub 2006 Sep 2. PMID:16951430 doi:10.1074/jbc.M606365200