Cluster of Differentiation CD38: Difference between revisions

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[[Image:3gc6a.jpg|left|200px|thumb|Crystal Structure of bovine Cluster of Differentiation 38 (CD38) [[3gc6]]]]
<StructureSection load='2i65' size='450' side='right' scene='42/422415/Cv/3' caption='Human Cluster of Differentiation 38 (CD38) complex with NAD [[2i65]]'>
{{STRUCTURE_3gc6|  PDB=3gc6  | SIZE=400| SCENE=Cluster_of_Differentiation_38/Cv/1 |right|CAPTION=Cluster of Differentiation 38 (CD38) complex with sulfate [[3gc6]] }}


[[Cluster of Differentiation 38]] (CD38), known also as ''ADP-ribosyl cyclase 1'' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR).  It is found on the surface of immune cells.  It also functions in cell adhesion, signal transduction and Ca++ signaling. The images at the left and at the right correspond to one representative CD38, ''i.e.'' the crystal structure of bovine Cluster of Differentiation 38 ([[3gc6]]).
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{{TOC limit|limit=2}}
== Function ==


[[Cluster of Differentiation 38]] (CD38), known also as '''ADP-ribosyl cyclase 1''' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR).  It is found on the surface of immune cells.  It also functions in cell adhesion, signal transduction and Ca+2 signaling.  '''ADP-ribosyl cyclase''' (ADPRC) is the ''Aplysia californica'' homolog of CD38.  It  catalyzes the synthesis and hydrolysis of cyclic ADP-ribose.  It uses  NAD+ as substrate and produces cyclic ADP-ribose (cADPR).<ref>PMID:16154090</ref>
== Relevance ==
CD38 is used as a marker for cell activation and for leukemia.
== Structural highlights ==
<scene name='42/422415/Cv/4'>CD38 active site contains NAD</scene>.<ref>PMID:16951430</ref>
</StructureSection>
== 3D Structures of Cluster of Differentiation 38 ==
== 3D Structures of Cluster of Differentiation 38 ==
    
    
''Update November 2011''
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
 
* CD38
 
**[[3gc6]] – bCD38 - bovine<br />
**[[3gh3]], [[3ghh]] – bCD38 residues 32-278<br />
**[[2eg9]] - CD38 enzymatic domain (mutant) – mouse<br />
**[[2ef1]] - hCD38 enzymatic domain – human<br />
**[[1yh3]] - hCD38 enzymatic domain (mutant)<br />
**[[1zvm]] -  hCD38 (mutant)<br />
**[[1isf]] – hADPRC2 (mutant) <br />
 
* CD38+ligand


=== CD38 ===
**[[3i9m]], [[3i9n]] – hCD38 enzymatic domain+ADPR analog<br /> 
**[[3f6y]] – hCD38 enzymatic domain+Ca++<br />
**[[3dzf]] - hCD38 enzymatic domain+intermediate<br />
**[[3dzg]] - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex<br />
**[[3dzh]] - hCD38 enzymatic domain (mutant)+GTP<br />
**[[3dzi]] - hCD38 enzymatic domain (mutant)+intermediate/GTP complex<br />
**[[3dzj]], [[3dzk]] - hCD38 enzymatic domain (mutant)+NMN complex<br />
**[[2pgj]], [[2pgl]] - hCD38 enzymatic domain (mutant)+substrate analog<br />
**[[2o3t]] - hCD38 enzymatic domain (mutant)+cGDPR<br />
**[[3u4h]], [[3u4i]] - hCD38 enzymatic domain (mutant)+cIDPR<br />
**[[2o3u]] - hCD38 enzymatic domain (mutant)+NGD <br />
**[[2o3q]], [[2o3r]], [[2o3s]] - hCD38 enzymatic domain (mutant)+cADPR<br />
**[[4f45]] - hCD38 enzymatic domain (mutant)+ NAADP<br />
**[[4f46]] - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP<br />
**[[4cmh]] - hCD38 enzymatic domain + antibody<br />
**[[2i65]] – hCD38+NAD<br />
**[[3kou]] - hCD38+NAD derivative<br />
**[[2i67]] - hCD38 (mutant)+ADPR<br />
**[[2hct]] -  hCD38 enzymatic domain (mutant)+NMN<br />
**[[3ofs]] - hCD38 enzymatic domain (mutant)+ ARA-2 F-ADPR<br />
**[[3raj]] - hCD38 enzymatic domain (mutant)+ FAB<br />
**[[3rok]], [[3rom]] - hCD38 (mutant) + arabinitol derivative<br />
**[[3roq]] - hCD38 (mutant) + hydrofuran derivative<br />
**[[3rop]] - hCD38 (mutant) + arabinitol derivative + nicotinamide<br />
**[[3p5s]] - bADPRC + arabinitol derivative<br />


*ADPRC


[[3gc6]] – bCD38 - bovine<br />
**[[1r12]] - AcADPRC - ''Aplysia californica''<br />
[[3gh3]], [[3ghh]] – bCD38 residues 32-278<br />  
**[[1r0s]] – AcADPRC (mutant) <br />
[[2eg9]] - CD38 enzymatic domain (mutant) – mouse<br />
[[2ef1]] - hCD38 enzymatic domain – human<br />
[[1yh3]] - hCD38 enzymatic domain (mutant)<br />
[[1zvm]] -  hCD38 (mutant)<br />


*ADPRC+ligand


=== CD38+ligand ===
**[[1r15]] -  AcADPRC+nicotinamide<br />
**[[3i9j]] – AcADPRC+nicotinamide+2F-NAD+2F-ADPRI<br />
**[[3i9k]] – AcADPRC (mutant)+NAD<br />
**[[3i9l]] – AcADPRC (mutant)+N1-CIDPR<br />
**[[3i9o]] – AcADPRC+Ribosyl-2F-ADPR<br />
**[[3zwx]], [[3zwy]] – AcADPRC + 8-Br-ADPR<br />
**[[1r16]] -  AcADPRC+3-pyridinylcarbinol<br />
**[[3zwm]] – AcADPRC + NAD + cADPR<br />
**[[3zwn]] – AcADPRC + NGD + cGDPR<br />
**[[3zwo]] – AcADPRC + NGD + GDPR<br />
**[[3zwp]], [[3zwv]], [[3zww]] – AcADPRC+ diphosphate ribosyl ara-2F-ADPR<br />




[[3i9m]], [[3i9n]] – hCD38 enzymatic domain+ADPR analog<br /> 
}}
[[3f6y]] – hCD38 enzymatic domain+Ca++<br />
== References ==
[[3dzf]] - hCD38 enzymatic domain+intermediate<br />
<references/>
[[3dzg]] - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex<br />
[[3dzh]] - hCD38 enzymatic domain (mutant)+GTP<br />
[[3dzi]] - hCD38 enzymatic domain (mutant)+intermediate/GTP complex<br />
[[3dzj]], [[3dzk]] - hCD38 enzymatic domain (mutant)+NMN complex<br />
[[2pgj]], [[2pgl]] - hCD38 enzymatic domain (mutant)+substrate analog<br />
[[2o3t]] - hCD38 enzymatic domain (mutant)+cGDPR<br />
[[2o3u]] - hCD38 enzymatic domain (mutant)+NGD <br />
[[2o3q]], [[2o3r]], [[2o3s]] - hCD38 enzymatic domain (mutant)+cADPR<br />
[[2i65]] – hCD38+NAD<br />
[[2i66]] - hCD38 (mutant)+GDP intermediate<br />
[[2i67]] - hCD38 (mutant)+ADPR<br />
[[2hct]] -  hCD38 enzymatic domain (mutant)+NMN<br />
[[3ofs]] - hCD38 enzymatic domain (mutant)+ ARA-2 F-ADPR<br />
[[3raj]] - hCD38 enzymatic domain (mutant)+ FAB


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 16:16, 10 July 2018


Function

Cluster of Differentiation 38 (CD38), known also as ADP-ribosyl cyclase 1 (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca+2 signaling. ADP-ribosyl cyclase (ADPRC) is the Aplysia californica homolog of CD38. It catalyzes the synthesis and hydrolysis of cyclic ADP-ribose. It uses NAD+ as substrate and produces cyclic ADP-ribose (cADPR).[1]

Relevance

CD38 is used as a marker for cell activation and for leukemia.

Structural highlights

.[2]

Human Cluster of Differentiation 38 (CD38) complex with NAD 2i65

Drag the structure with the mouse to rotate

3D Structures of Cluster of Differentiation 383D Structures of Cluster of Differentiation 38

Updated on 10-July-2018

ReferencesReferences

  1. ↑ Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q. Crystal structure of human CD38 extracellular domain. Structure. 2005 Sep;13(9):1331-9. PMID:16154090 doi:http://dx.doi.org/10.1016/j.str.2005.05.012
  2. ↑ Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q. Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis. J Biol Chem. 2006 Oct 27;281(43):32861-9. Epub 2006 Sep 2. PMID:16951430 doi:10.1074/jbc.M606365200

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