Stimulator of interferon genes protein

Function Stimulator of interferon genes protein or transmembrane protein 173 (STING) is an ER-associated membrane protein. STING signals immune responses in human and other animals. STING is activated by cyclic GMP-AMP produced by Cyclic GMP-AMP synthase whose activity is triggered by infections of DNA-containing pathogens. A PLPLRT/SD conserved motif at the STING C-terminal plays a critical role in turning on the immune system to fight against viral infections. Disease STING mutations are associated with autoimmune diseases. Structural highlights The 3D structure of the complex between human STING and cyclic GMP-AMP shows the dinucleotide bound by the symmetric dimer of STING. The U-shaped cleft between the 2 subunits makes numerous interactions with the U-shaped ligand. A Tyr residue from each monomer stacks against each of the purine moieties while an Arg residue from each monomer forms hydrogen bonds to the dinucleotide .

spinqualitylabelsall models Human stimulator of interferon genes protein C-di-GMP-binding domain complex with GMP-AMP (PDB code 4loh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of stimulator of interferon genes protein3D structures of stimulator of interferon genes protein

Updated on 16-February-2023

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• Stimulator of interferon genes protein; domains - C-di-GMP-binding 154-341; PLPLRT/SD motif 342-379
  • 6nt5 – hSTING - human - Cryo EM
    
  • 4ef5, 4f5w, 4f9e – hSTING C-di-GMP-binding domain
    
  • 4f5e, 6mx0 – hSTING C-di-GMP-binding domain (mutant)
    
  • 6iyf – pSTING C-di-GMP-binding domain - pig
    
  • 4kc0 – mSTING C-di-GMP-binding domain - mouse
    
  • 5gs5 – rSTING C-di-GMP-binding domain - rat
    
  • 6nt6 – cSTING - chicken - Cryo EM
    
  • 5cfo, 5cfr – aSTING – anemone
    
• Stimulator of interferon genes protein complex
  • 4ef4, 4emt, 4emu, 4f5y, 4f9g, 6s86 – hSTING C-di-GMP-binding domain + GMP derivative
    
  • 4f5d – hSTING C-di-GMP-binding domain (mutant) + GMP derivative
    
  • 6cff, 6cy7 – hSTING C-di-GMP-binding domain + AMP derivative
    
  • 4ksy, 4loh, 5bqx, 6dnk, 6xnp, 6s26, 6s27 – hSTING C-di-GMP-binding domain + GMP-AMP derivative
    
  • 4loi, 6mx3, 6mxe – hSTING C-di-GMP-binding domain (mutant) + GMP-AMP derivative
    
  • 6dxg, 6dxl, 6ukm, 6uku, 6ukv, 6ukw, 6ukx, 6uky, 6ukz, 6ul0 – hSTING C-di-GMP-binding domain + agonist
    
  • 4qxo – hSTING C-di-GMP-binding domain + drug
    
  • 4qxp, 4qxq, 4qxr – hSTING C-di-GMP-binding domain (mutant) + drug
    
  • 5jej – hSTING PLPLRT/SD motif + IRF-3 CTD
    
  • 6o8b, 6o8c – hSTING PLPLRT/SD motif (mutant) + TBK1
    
  • 6a03, 6a04, 6a05, 6a06 – pSTING C-di-GMP-binding domain + ligand
    
  • 4kby – mSTING C-di-GMP-binding domain+ GMP derivative
    
  • 4loj, 4lok, 4yp1 – mSTING C-di-GMP-binding domain + GMP-AMP derivative
    
  • 6xnn – mSTING C-di-GMP-binding domain + GMP-AMP derivative
    
  • 4lol – mSTING C-di-GMP-binding domain + drug
    
  • 4jc5 – mSTING C-di-GMP-binding domain + immune activator
    
  • 5grm – rSTING C-di-GMP-binding domain + GMP-AMP derivative
    
  • 6nt7, 6nt8 – cSTING + GMP-AMP derivative - Cryo EM
    
  • 6nt9 – cSTING + TBK1 - Cryo EM
    
  • 5cfl, 5cfm, 5cfq – aSTING C-di-GMP-binding domain + GMP derivative
    
  • 5cfp – aSTING C-di-GMP-binding domain (mutant) + GMP derivative
    
  • 5cfn – aSTING C-di-GMP-binding domain + AMP derivative