Proteopedia

Cyclic GMP-AMP synthase


Function

Cyclic GMP-AMP synthase (CGAS) binds to DNA and catalyzes cGAMP synthesis. The cGAMP activates the type-I interferon pathway. [1]

Disease

Mice lacking CGAS are more vulnerable to lethal infection by DNA virus.

Structural highlights

The .[2]

3D structures of cyclic GMP-AMP structures

Cyclic GMP-AMP synthase 3D structures


Structure of human cyclic GMP-AMP synthase complex with c-GAMP and Zn+2 (grey) ions (PDB code 4o67).

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458
  2. ↑ Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Zhang X, Chen ZJ. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Rep. 2014 Feb 13;6(3):421-30. doi: 10.1016/j.celrep.2014.01.003. Epub 2014, Jan 23. PMID:24462292 doi:http://dx.doi.org/10.1016/j.celrep.2014.01.003

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Michal Harel, Alexander Berchansky, Joel L. Sussman
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