Enoyl-Acyl-Carrier Protein Reductase

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Function

Enoyl-Acyl-Carrier Protein Reductase (ENR) is an enzyme in the fatty acid synthesis. For additional details see

Relevance

ENR is a target of anti-bacterial drugs such as triclosan (TCL). These drugs are used against tuberculosis infection.

Structural highlights

. InhA ENR .[1]

3D Structures of Enoyl-Acyl-Carrier Protein Reductase

Enoyl-Acyl-Carrier Protein Reductase 3D structures


Enoyl-Acyl-Carrier Protein Reductase tetramer complex with NAD and triclosan derivative (PDB code 3fne)

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ReferencesReferences

  1. ↑ Freundlich JS, Wang F, Vilcheze C, Gulten G, Langley R, Schiehser GA, Jacobus DP, Jacobs WR Jr, Sacchettini JC. Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis. ChemMedChem. 2009 Jan 7. PMID:19130456 doi:10.1002/cmdc.200800261

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Alexander Berchansky, Michal Harel
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