Diguanylate cyclase

Function Diguanylate cyclase (DGC) catalyzes the conversion of GTP to C-di-GMP and diphosphate. For more details see PleD catalysis PleD activation PleD allosteric product inhibition C-di-GMP signaling. Relevance DGC from Borrelia burgdorferi is involved in the transmission of spirochetes from ticks to mammals causing Lyme Disease. Structural highlights DGC contains the sequence in its active site. of DGC.

spinqualitylabelsall models Diguanylate cyclase GGDEF domain complex with cyclic di-GMP, Mg+2 ion (green) and PEG (PDB code 3qyy). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of diguanylate cyclase3D Structures of diguanylate cyclase

Updated on 21-December-2022

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• DGC
  • 4urg, 6khu – TmDGC GGDEF domain 82-248 – Thermotoga maritima
    
  • 4urq – TmDGC GGDEF domain (mutant)
    
  • 3ign – MaDGC GGDEF domain – Marinobacter aquaeolei
    
  • 3h9w – MaDGC N terminal
    
  • 4zmu – PaDGC – Pseudomonas aeruginosa
    
  • 3hvw, 4iob – DGC GGDEF domain 254-414
    
  • 7a7e – PaDGC GGDEF domain (mutant)
    
  • 4zmm – PaDGC GGDEF domain + C-diGMP
    
  • 5m3c – PaDGC GGDEF domain + GTP
    
  • 7e6g – PaDGC GGDEF domain + SiaC
    
  • 3n53 – DGC – Pelobacter carbinolicus
    
  • 5h5o – XcDGC residues 1-150 – Xanthomonas campestris
    
  • 3qyy – XcDGC GGDEF domain + cyclic di-GMP
    
  • 4urs – TmDGC GGDEF domain + cyclic di-GMP
    
  • 3t9o – EcDGC YDEH CZB domain – Escherichia coli
    
  • 3tvk, 4zve, 4zvg, 4zvh – EcDGC YDEH GGDEF domain
    
  • 4h54 – EcDGC YDEH (mutant)
    
  • 4zva, 4zvb – EcDGC globin domain
    
  • 4zvc, 4zvd – EcDGC mid domain
    
  • 4zvf – EcDGC GGDEF domain 297-460 + GTP derivative
    
  • 6eib – DGC GGDEF domain – Vibrio cholerae
    
  • 6et7 – IdDGC (mutant) - Idiomarina
    
  • 5llw, 5lly – IdDGC + phytochromobilin
    
  • 5llx – IdDGC + phytochromobilin + GTP
    
  • 6saw, 6sax – IdDGC chromophore-binding domain 3-312
    
  • 6hbz – DGCB – Bdellovibrio bacteriovorus
    
  • 6tts – CvDGCB GGDEF domain 176-353 + C-diGMP – Caulobacter vibrioides
    
  • 6ttr – CvDGCB GGDEF+coiled-coil domains 153-353 (mutant) + C-diGMP
    
  • 7k5n – DGC LBD domain 39-286 + Pro – Aeromonas caviae
    
• Response regulator PleD
  • 1w25, 2wb4 – CvDGC + cyclic di-GMP
    
  • 2v0n – CvDGC + cyclic di-GMP + GTP