Beta secretase 3D structures

2zhs, 2zht, 2zhu, 2zhv, 1sgz - hBACE-1 catalytic domain – human

1w50, 3tpj, 3tpl, 3zkg - hBACE-1 catalytic domain (mutant)

3k5d, 3k5f, 3k5g, 3ixj, 3kmx, 3kmy, 3kn0, 3ivh, 3ivi, 2vkm, 2hiz, 2hm1, 2g94, 1xs7, 4fm7, 4fm8, 4gid, 4i0h, 5dqc, 5qco, 5qcp, 5qcq, 5qcr, 5qcs, 5qct, 5qcu, 5qcv, 5qcw, 5qcx, 5qcy, 5qcz, 5dq1, 5dq2, 5dq3, 5dq4, 5dq5, 5dq6, 5dq7, 5dq8, 5dq9, 5dqa, 5dqb, 5dqc, 5dqd, 6ej2, 6ej3, 7d2v, 7d2x, 7d36, 7d5a, 7dcz, 7f1d, 7myi, 7myr, 7myu, 7n66 – hBACE-1 catalytic domain+inhibitor

3lhg, 3ind, 3in3, 3in4, 3ine, 3inf, 3inh, 3ooz, 3s7l, 3s7m, 4dju, 4djv, 4djw, 4djx, 4djy – hBACE-1 catalytic domain+ aminohydantoin inhibitor

3fkt – hBACE-1 catalytic domain (mutant) + aminohydantoin inhibitor

3k5c, 3l58, 3l59, 3l5b, 3l5c, 3l5d, 3l5e, 3l5f, 3duy, 3dv1, 3dv5, 2f3e, 2f3f, 1ym2, 1ym4, 3skf, 3skg, 4h1e, 4h3j, 4ha5, 4gmi, 4k8s, 4k9h, 6nv7, 6nv9, 6nw3 – hBACE-1 catalytic domain+ macrocyclic inhibitor

3ckp, 3ckr, 2qzk, 2ph8, 2va5, 2va6, 2va7, 2ph6, 4ke0, 4ke1, 6uj1 – hBACE-1 catalytic domain (mutant) + macrocyclic inhibitor

3ohh, 3ohf, 3n4l, 3nsh, 2iqg, 3pi5, 3qbh, 4dpf, 4dpi, 4dus, 4fs4, 4ewo, 4exg, 3veu, 3vf3, 3vg1, 4d83, 4d85, 4d88], 4d89, 4d8c, 3qi1, 4lxa, 4lxk, 4lxm – hBACE-1 catalytic domain+ hydroxyethylamine inhibitor

3i25 – hBACE-1 catalytic domain+ hydroxyethylene inhibitor

3udh, 2qmg, 2qmd, 2qmf, 3ufl, 3udj, 3udk, 3udm, 3udn, 3udp, 3udq, 3udr, 3udy, 3r2f, 3uqr, 6bfd, 6bfe, 6bfx – hBACE-1 catalytic domain+ pyrrolydine inhibitor

2wez, 2wf0, 6bfd, 6bfe, 6bfx, 3hw1, 3uqp, 4dv9, 4dvf – hBACE-1 catalytic domain (mutant) + pyrrolydine inhibitor

4lc7, 4rcd, 4rce, 4rcf, 4wtu, 5enm, 5enk, 5uyu, 6dhc – hBACE-1 catalytic domain+ oxazoline inhibitor

4xkx, 5i3w, 5ezz, 5ezx, 5clm, 4fri, 4frj, 4frk – hBACE-1 catalytic domain (mutant) + oxazoline inhibitor

5ygx, 5yxy – hBACE-1 catalytic domain + oxazine inhibitor

6fgy – hBACE-1 catalytic domain (mutant) + oxazine inhibitor

5v0n, 3lnk, 3lpi, 3lpj, 3lpk, 3cib, 3cic, 3cid, 3u6a, 6od6 – hBACE-1 catalytic domain + piperazine inhibitor

2zjk, 2zjj - hBACE-1 catalytic domain (mutant) + piperazine inhibitor

2zjh, 2zji, 2zjl, 2zjm, 2jzn, 2ohn, 4fco - hBACE-1 catalytic domain (mutant) + piperidine inhibitor

6bfw – hBACE-1 catalytic domain + morpholine inhibitor

2of0 – hBACE-1 catalytic domain (mutant) + morpholine inhibitor

6c2i, 4i0j, 6jse, 6jsf, 6jsn, 6jt3, 6jt4, 6pz4 – hBACE-1 catalytic domain + pyrazine inhibitor

5qd0 – hBACE-1 catalytic domain + pyrazole inhibitor

3kyr, 3dm6 – hBACE-1 catalytic domain + statine inhibitor

2qk5, 2qp8, 2p8h, 2p4j, 2p83, 2fdp, 3ixk, 3tpr – hBACE-1 catalytic domain + phthalamide inhibitor

2qzl, 2is0, 2b8l, 3tpp – hBACE-1 catalytic domain (mutant) + phthalamide inhibitor

3wb4, 3wb5, 5he7, 5he5, 5he4, 5hdz, 5hdx, 5hdv, 5hdu, 5hd0, 4frs, 3vv6, 3vv7, 3vv8, 4h3f, 4h3g, 4h3i, 4l7g, 4l7h, 4l7j - hBACE-1 catalytic domain + pyrimidine inhibitor

3zki, 3hvg, 3exo - hBACE-1 catalytic domain (mutant) + pyrimidine inhibitor

3igb, 4acu, 4b1c, 4b1d, 4b1e, 4b70, 4b72, 4b77, 4n00, 3msj, 3msk, 3msl, 3s2o, 4joo, 4jp9, 4jpc, 4jpe – hBACE-1 catalytic domain+ imidazole inhibitor

4acx – hBACE-1 catalytic domain (mutant) + imidazole inhibitor

2zdz, 2ze1, 2qu2, 2qu3, 4fse, 4fsl, 4b0q – hBACE-1 catalytic domain+ acyl guanidine inhibitor

4ivs, 4ivt – hBACE-1 catalytic domain (mutant) + acyl guanidine inhibitor

2q11, 2q15, 4i0e, 4i0f, 4i0g, 4i10, 4i11, 4i12, 4i1c, 5mxd, 2wjo – hBACE-1 catalytic domain+ quinazoline inhibitor

2vnm, 2vnn, 2vie, 2vij, 2viy, 2viz, 2vj6, 2vj7, 2vj9, 4dh6, 4di2 – hBACE-1 catalytic domain (mutant) + hydroxyethylamine inhibitor

4b78, 3l38, 3l3a, 6eqm, 6dmi, 6e3z, 6jsg, 6uvp, 7b1e, 7b1p, 7b1q, 7d2v, 7d2x, 7d5a, 7dcz – hBACE-1 catalytic domain + pyridine inhibitor

2ohq, 2ohr, 2ohs, 2oht, 2ohu, 2ohp, 4j0p, 2ntr, 2ohm, 4azy, 4b00, 4b05, 3zmg, 4j0t, 4j0v, 4j0y, 4j0z, 4j1i, 4j1k, 3zov, 4bfd – hBACE-1 catalytic domain (mutant) + pyridine inhibitor

2b8v, 2irz, 2xfi, 2xfj, 2xfk, 1w51 – hBACE-1 catalytic domain (mutant) + benzamide inhibitor

4pzw, 4pzx, 4r5n, 4rrn, 4rro, 4rrs, 4wy1, 4wy6 – hBACE-1 catalytic domain + pyranochromene inhibitor

4r8y, 4r91, 4r92, 4r93, 4r95, 3h0b – hBACE-1 catalytic domain + iminoheterocycle inhibitor

4x2l, 4x7i, 5kqf, 5hu1, 4zsr, 4zsq, 4zsp, 4zsm, 4zpg, 4zpf, 4zpe, 4ybi, 4xxs, 6uvv, 6uvy, 6uwp, 6uwv – hBACE-1 catalytic domain + thiazine inhibitor

5tol, 5kr8, 4bek – hBACE-1 catalytic domain (mutant) + thiazine inhibitor

5t1w, 5t1u – hBACE-1 catalytic domain + aminomethyl inhibitor

3bra, 3buf, 3bug, 3buh - hBACE-1 catalytic domain (mutant) + aminomethyl inhibitor

5hu0, 5htz – hBACE-1 catalytic domain + thiadiazinane inhibitor

2wf1, 2wf2, 2wf3, 2wf4 - hBACE-1 catalytic domain (mutant) + thiazepine inhibitor

4trz, 4try, 4trw – hBACE-1 catalytic domain + peptide mimetic inhibitor

5ie1, 4hzt, 4i0z – hBACE-1 catalytic domain + quinoline inhibitor

3rsv, 3rsx, 3rth, 3rtm, 3rtn, 3ru1, 3rvi, 5i3y, 5i3x, 5i3v, 5f01, 5f00, 2ohk, 2ohl – hBACE-1 catalytic domain (mutant) + aminoquinoline inhibitor

4i0d, 4i0i – hBACE-1 catalytic domain + thiophene inhibitor

4acx – hBACE-1 catalytic domain (mutant) + aminoimidazole inhibitor

2zhr, 1xn2, 1xn3, 1m4h, 1fkn, 5mcq - hBACE-1 catalytic domain + peptide inhibitor

5mbw, 5mco, 6uj0 - hBACE-1 catalytic domain (mutant) + peptide inhibitor

6wny – hBACE-1 catalytic domain + fluoro-olefin inhibitor

2oah, 1tqf, 3uqp, 3uqr, 3uqu, 3uqw, 3uqx, 4fgx - hBACE-1 catalytic domain (mutant)+inhibitor

3r1g - hBACE-1 catalytic domain + FAB

3D Structures of Beta secretase3D Structures of Beta secretase

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