Cluster of Differentiation CD38

Function Cluster of Differentiation 38 (CD38), known also as ADP-ribosyl cyclase 1 (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca+2 signaling. ADP-ribosyl cyclase (ADPRC) is the Aplysia californica homolog of CD38. It catalyzes the synthesis and hydrolysis of cyclic ADP-ribose. It uses NAD+ as substrate and produces cyclic ADP-ribose (cADPR). Relevance CD38 is used as a marker for cell activation and for leukemia. Structural highlights .

spinqualitylabelsall models Human Cluster of Differentiation 38 (CD38) complex with NAD 2i65 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Cluster of Differentiation 383D Structures of Cluster of Differentiation 38

Updated on 10-July-2018

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• CD38
  • 3gc6 – bCD38 - bovine
    
  • 3gh3, 3ghh – bCD38 residues 32-278
    
  • 2eg9 - CD38 enzymatic domain (mutant) – mouse
    
  • 2ef1 - hCD38 enzymatic domain – human
    
  • 1yh3 - hCD38 enzymatic domain (mutant)
    
  • 1zvm - hCD38 (mutant)
    
  • 1isf – hADPRC2 (mutant)
    
• CD38+ligand
  • 3i9m, 3i9n – hCD38 enzymatic domain+ADPR analog
    
  • 3f6y – hCD38 enzymatic domain+Ca++
    
  • 3dzf - hCD38 enzymatic domain+intermediate
    
  • 3dzg - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex
    
  • 3dzh - hCD38 enzymatic domain (mutant)+GTP
    
  • 3dzi - hCD38 enzymatic domain (mutant)+intermediate/GTP complex
    
  • 3dzj, 3dzk - hCD38 enzymatic domain (mutant)+NMN complex
    
  • 2pgj, 2pgl - hCD38 enzymatic domain (mutant)+substrate analog
    
  • 2o3t - hCD38 enzymatic domain (mutant)+cGDPR
    
  • 3u4h, 3u4i - hCD38 enzymatic domain (mutant)+cIDPR
    
  • 2o3u - hCD38 enzymatic domain (mutant)+NGD
    
  • 2o3q, 2o3r, 2o3s - hCD38 enzymatic domain (mutant)+cADPR
    
  • 4f45 - hCD38 enzymatic domain (mutant)+ NAADP
    
  • 4f46 - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP
    
  • 4cmh - hCD38 enzymatic domain + antibody
    
  • 2i65 – hCD38+NAD
    
  • 3kou - hCD38+NAD derivative
    
  • 2i67 - hCD38 (mutant)+ADPR
    
  • 2hct - hCD38 enzymatic domain (mutant)+NMN
    
  • 3ofs - hCD38 enzymatic domain (mutant)+ ARA-2 F-ADPR
    
  • 3raj - hCD38 enzymatic domain (mutant)+ FAB
    
  • 3rok, 3rom - hCD38 (mutant) + arabinitol derivative
    
  • 3roq - hCD38 (mutant) + hydrofuran derivative
    
  • 3rop - hCD38 (mutant) + arabinitol derivative + nicotinamide
    
  • 3p5s - bADPRC + arabinitol derivative
    
• ADPRC
  • 1r12 - AcADPRC - Aplysia californica
    
  • 1r0s – AcADPRC (mutant)
    
• ADPRC+ligand
  • 1r15 - AcADPRC+nicotinamide
    
  • 3i9j – AcADPRC+nicotinamide+2F-NAD+2F-ADPRI
    
  • 3i9k – AcADPRC (mutant)+NAD
    
  • 3i9l – AcADPRC (mutant)+N1-CIDPR
    
  • 3i9o – AcADPRC+Ribosyl-2F-ADPR
    
  • 3zwx, 3zwy – AcADPRC + 8-Br-ADPR
    
  • 1r16 - AcADPRC+3-pyridinylcarbinol
    
  • 3zwm – AcADPRC + NAD + cADPR
    
  • 3zwn – AcADPRC + NGD + cGDPR
    
  • 3zwo – AcADPRC + NGD + GDPR
    
  • 3zwp, 3zwv, 3zww – AcADPRC+ diphosphate ribosyl ara-2F-ADPR