6d0a

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Crystal structure of Kynurenine Aminotransferase-II in apo-form, at 1.47 A resolutionCrystal structure of Kynurenine Aminotransferase-II in apo-form, at 1.47 A resolution

Structural highlights

6d0a is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.4680942Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AADAT_HUMAN Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).[1]

See Also

References

  1. Han Q, Cai T, Tagle DA, Robinson H, Li J. Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II. Biosci Rep. 2008 Aug;28(4):205-15. PMID:18620547 doi:10.1042/BSR20080085

6d0a, resolution 1.47Å

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OCA