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Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) C217A, C239A bound to FMNCrystal structure of Mus musculus iodotyrosine deiodinase (IYD) C217A, C239A bound to FMN
Structural highlights
FunctionIYD1_MOUSE Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine (By similarity). See Also |
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