2dm7

Solution structure of the 14th Ig-like domain of human KIAA1556 proteinSolution structure of the 14th Ig-like domain of human KIAA1556 protein

Structural highlights

2dm7 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

OBSCN_HUMAN Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Young P, Ehler E, Gautel M. Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. J Cell Biol. 2001 Jul 9;154(1):123-36. PMID:11448995
↑ Borisov AB, Sutter SB, Kontrogianni-Konstantopoulos A, Bloch RJ, Westfall MV, Russell MW. Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing. Histochem Cell Biol. 2006 Mar;125(3):227-38. Epub 2005 Oct 5. PMID:16205939 doi:http://dx.doi.org/10.1007/s00418-005-0069-x

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OCA

[1] Young P, Ehler E, Gautel M. Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. J Cell Biol. 2001 Jul 9;154(1):123-36. PMID:11448995

[2] Borisov AB, Sutter SB, Kontrogianni-Konstantopoulos A, Bloch RJ, Westfall MV, Russell MW. Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing. Histochem Cell Biol. 2006 Mar;125(3):227-38. Epub 2005 Oct 5. PMID:16205939 doi:http://dx.doi.org/10.1007/s00418-005-0069-x

[1]

[2]

2dm7

Solution structure of the 14th Ig-like domain of human KIAA1556 proteinSolution structure of the 14th Ig-like domain of human KIAA1556 protein

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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2dm7

Solution structure of the 14th Ig-like domain of human KIAA1556 proteinSolution structure of the 14th Ig-like domain of human KIAA1556 protein

Structural highlights

Function

Evolutionary Conservation

See Also

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

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