Obscurin

Function Obscurin (Obs) or KIAA1556 is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see Group:MUZIC:Obscurin. Disease Mutations of Obs are found in hypertrophy cardiomyopathy.

spinqualitylabelsall models Human obscurin of 32th IG-like domain residues 3184-3273 (PDB entry 2yz8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of obscurin3D structures of obscurin

17-August-2023

{"openlevels":0}

• Obscurin
  • 2e7b - hObs 6th Ig domain residues 8-97 – human - NMR
    
  • 2eo1 - hObs Ig domain residues 69-163 – NMR
    
  • 7r68 - hObs 12th Ig domain residues 1071-1162 – NMR
    
  • 2dm7, 7r67 - hObs 13th Ig domain residues 1161-1254 – NMR
    
  • 2gqh - hObs 15th Ig domain residues 1253-1346 – NMR
    
  • 2eny - hObs Ig domain residues 2735-2825 – NMR
    
  • 2edf - hObs 2nd Ig domain residues 2826-2915 – NMR
    
  • 2dku - hObs 3rd Ig domain residues 2915-3004 – NMR
    
  • 2cr6 - hObs Ig domain residues 2998-3100 – NMR
    
  • 2yz8 - hObs 32nd Ig domain residues 3184-3273
    
  • 2edr - hObs Ig domain residues 3361-3449 – NMR
    
  • 2edt - hObs Ig domain residues 3449-3537 – NMR
    
  • 2edw - hObs I-set domain residues 3537-3630 – NMR
    
  • 2edh – hObs PDZ domain residues 3614-3713 – NMR
    
  • 2edq - hObs Ig domain residues 3713-3806 – NMR
    
  • 2edl - hObs Ig domain residues 3801-3897 – NMR
    
  • 6mg9 - hObs 57th Ig domain residues 4247-4338 – NMR
    
  • 2mwc, 4rsv - hObs 58th Ig domain residues 4337-4429 – NMR
    
  • 5tzm - hObs 59th Ig domain residues 4946-5036
    
  • 2n56 - hObs 59th Ig domain residues 4430-4524 – NMR
    
  • 1v1c - hObs SH3 domain residues 5601-5668 – NMR
    
  • 8ak2 - DmObs kinase domain residues 3186-3480 – Drosophila melanogaster
    
  • 8ak3 - DmObs kinase domain + ADP
    
• Obscurin-like protein 1
  • 5fm5 - hObsL 3rd Ig domain residues 251-339 + myomesin-1
    
  • 2e6q - hObsL Ig domain residues 615-713 – NMR
    
  • 2e6p - hObsL Ig domain residues 714-804 – NMR
    
  • 2lvc - hObsL 6th Ig domain residues 805-892 – NMR
    
  • 2lu7 - hObsL 11th Ig domain residues 1277-1357 – NMR
    
  • 3knb, 2wp3, 2wwm, 4c4k – hObsL N terminal residues 1-105 + titin M10 domain
    
  • 2wwk – hObsL N terminal residues (mutant) + titin M10 domain
    
  • 4uow - hObsL residues 26829-26925 + titin M10 domain