1v6b

Solution structure of the third PDZ domain of mouse harmoninSolution structure of the third PDZ domain of mouse harmonin

Structural highlights

1v6b is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

USH1C_MOUSE Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Grillet N, Xiong W, Reynolds A, Kazmierczak P, Sato T, Lillo C, Dumont RA, Hintermann E, Sczaniecka A, Schwander M, Williams D, Kachar B, Gillespie PG, Muller U. Harmonin mutations cause mechanotransduction defects in cochlear hair cells. Neuron. 2009 May 14;62(3):375-87. doi: 10.1016/j.neuron.2009.04.006. PMID:19447093 doi:http://dx.doi.org/10.1016/j.neuron.2009.04.006

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OCA

[1] Grillet N, Xiong W, Reynolds A, Kazmierczak P, Sato T, Lillo C, Dumont RA, Hintermann E, Sczaniecka A, Schwander M, Williams D, Kachar B, Gillespie PG, Muller U. Harmonin mutations cause mechanotransduction defects in cochlear hair cells. Neuron. 2009 May 14;62(3):375-87. doi: 10.1016/j.neuron.2009.04.006. PMID:19447093 doi:http://dx.doi.org/10.1016/j.neuron.2009.04.006

[1]

1v6b

Solution structure of the third PDZ domain of mouse harmoninSolution structure of the third PDZ domain of mouse harmonin

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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1v6b

Solution structure of the third PDZ domain of mouse harmoninSolution structure of the third PDZ domain of mouse harmonin

Structural highlights

Function

Evolutionary Conservation

See Also

References

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