Crystal structure of a hemagglutinin component (HA1) from type C Clostridium botulinumCrystal structure of a hemagglutinin component (HA1) from type C Clostridium botulinum
Structural highlights
1qxm is a 2 chain structure with sequence from Clostridium botulinum D phage. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
HA33D_CBDP The hemagglutinin (HA) component of the progenitor toxin protects the structural integrity of the neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host. Involved in binding to the small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties (By similarity). Erythrocyte agglutination only occurs when the entire complex is assembled (PubMed:17581814). Binds eukaryotic host mucins as well as N-acetyl-beta-neuraminic acid, N-acetyl-D-galactosamine and galactose (but not glucose) via 2 sites (By similarity).[UniProtKB:P0DPR0][1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Hasegawa K, Watanabe T, Suzuki T, Yamano A, Oikawa T, Sato Y, Kouguchi H, Yoneyama T, Niwa K, Ikeda T, Ohyama T. A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms. J Biol Chem. 2007 Aug 24;282(34):24777-83. Epub 2007 Jun 20. PMID:17581814 doi:10.1074/jbc.M703446200
