1dj7

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CRYSTAL STRUCTURE OF FERREDOXIN THIOREDOXIN REDUCTASECRYSTAL STRUCTURE OF FERREDOXIN THIOREDOXIN REDUCTASE

Structural highlights

1dj7 is a 2 chain structure with sequence from Synechocystis sp. PCC 6803. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FTRC_SYNY3 Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.[1] [2] [3] [4]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Light generates reducing equivalents in chloroplasts that are used not only for carbon reduction, but also for the regulation of the activity of chloroplast enzymes by reduction of regulatory disulfides via the ferredoxin:thioredoxin reductase (FTR) system. FTR, the key electron/thiol transducer enzyme in this pathway, is unique in that it can reduce disulfides by an iron-sulfur cluster, a property that is explained by the tight contact of its active-site disulfide and the iron-sulfur center. The thin, flat FTR molecule makes the two-electron reduction possible by forming on one side a mixed disulfide with thioredoxin and by providing on the opposite side access to ferredoxin for delivering electrons.

Redox signaling in chloroplasts: cleavage of disulfides by an iron-sulfur cluster.,Dai S, Schwendtmayer C, Schurmann P, Ramaswamy S, Eklund H Science. 2000 Jan 28;287(5453):655-8. PMID:10649999[5]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Dai S, Schwendtmayer C, Schurmann P, Ramaswamy S, Eklund H. Redox signaling in chloroplasts: cleavage of disulfides by an iron-sulfur cluster. Science. 2000 Jan 28;287(5453):655-8. PMID:10649999
  2. ↑ Glauser DA, Bourquin F, Manieri W, Schürmann P. Characterization of ferredoxin:thioredoxin reductase modified by site-directed mutagenesis. J Biol Chem. 2004 Apr 16;279(16):16662-9. PMID:14769790 doi:10.1074/jbc.M313851200
  3. ↑ Dai S, Friemann R, Glauser DA, Bourquin F, Manieri W, Schurmann P, Eklund H. Structural snapshots along the reaction pathway of ferredoxin-thioredoxin reductase. Nature. 2007 Jul 5;448(7149):92-6. PMID:17611542 doi:http://dx.doi.org/10.1038/nature05937
  4. ↑ Xu X, Schürmann P, Chung JS, Hass MA, Kim SK, Hirasawa M, Tripathy JN, Knaff DB, Ubbink M. Ternary protein complex of ferredoxin, ferredoxin:thioredoxin reductase, and thioredoxin studied by paramagnetic NMR spectroscopy. J Am Chem Soc. 2009 Dec 9;131(48):17576-82. PMID:19908864 doi:10.1021/ja904205k
  5. ↑ Dai S, Schwendtmayer C, Schurmann P, Ramaswamy S, Eklund H. Redox signaling in chloroplasts: cleavage of disulfides by an iron-sulfur cluster. Science. 2000 Jan 28;287(5453):655-8. PMID:10649999

1dj7, resolution 1.60Å

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