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Ferredoxin thioredoxin reductase


Ferredoxin thioredoxin reductase (FTR) is a regulatory iron-sulfur enzyme of oxygenic photosynthetic cells . It catalyzes the 2-electron reduction of the disulfide of thioredoxin (Trx) with electrons from ferredoxin (Fd). It contains a catalytic subunit (FTR-C) and variable subunit (FTR-V)[1].

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(2pvg).[2] Water molecules are shown as red spheres.

Ferredoxin thioredoxin reductase catalytic (magenta) and variable (green) subunits complex with ferredoxin I (cyan) with Fe2S2 and Fe4S4 clusters 2pvg

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3D Structures of ferredoxon thioredoxin reductase3D Structures of ferredoxon thioredoxin reductase

Updated on 25-July-2021

7c3f - AtFTR-C + FTR-V+Trx-M2 – Arabidopsis thaliana
7c2b - AtFTR-C + FTR-V+Trx-F2
7bzk - AtFTR-C + Trx-Y1
1dj7 – SyFTR-C +FTR-V – Synechocystis
2pu9 - SyFTR-C +FTR-V+Trx-F (mutant)
2puk - SyFTR-C +FTR-V (mutant)+Trx-M
2puo, 2pvd - SyFTR-C +FTR-V
2pvg - SyFTR-C +FTR-V+Fd-1
2pvo - SyFTR-C +FTR-V+Trx-F + Fd-1

ReferencesReferences

  1. ↑ Buchanan BB, Schurmann P, Wolosiuk RA, Jacquot JP. The ferredoxin/thioredoxin system: from discovery to molecular structures and beyond. Photosynth Res. 2002;73(1-3):215-22. PMID:16245124 doi:http://dx.doi.org/10.1023/A:1020407432008
  2. ↑ Dai S, Friemann R, Glauser DA, Bourquin F, Manieri W, Schurmann P, Eklund H. Structural snapshots along the reaction pathway of ferredoxin-thioredoxin reductase. Nature. 2007 Jul 5;448(7149):92-6. PMID:17611542 doi:http://dx.doi.org/10.1038/nature05937

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