CAMP-dependent protein kinase 3D structures

3D structures of cAMP-dependent protein kinase3D structures of cAMP-dependent protein kinase

Updated on 01-January-2025

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• PKA catalytic subunit
  • 4ae6, 4ae9 – hPKA 2 – human
    
  • 8x5l – hPKA alpha
  • 1j3h – mPKA – mouse
  • 1syk, 4dfy, 4nts - mPKA (mutant)
  • 6eh0 – haPKA – hamster
    
  • 1fot - yPKA – yeast
    
• PKA catalytic subunit binary complex
  • 6c0u, 6you, 7y1g - hPKA + inhibitor
    
  • 3agl, 3agm – hPKA + bisubstrate inhibitor
    
  • 3bwj - bPKA + bisubstrate inhibitor
    
  • 1szm - bPKA + bisindolymaleimide
    
  • 3ag9, 8sf8 - bPKA + inhibitor
    
  • 7lz4 – bPKA (mutant) + CMP
    
  • 5n1f, 5n1g, 5n1h, 5n3g, 5n3h, 5n3i, 5n3j, 5n3k, 5n3l, 5n3m, 5n3n, 5n3o, 5n3p, 5n3q, 5n3r, 5n3s, 5n3t - haPKA + fragment molecule
    
  • 6em2, 6sq1 - haPKA + drug
    
  • 6snn, 6snx, 6sox, 6spm, 6sps, 6spu, 6z44 - haPKA + benzoic acid derivative
    
  • 6spy - haPKA + pyridine derivative
    
  • 6zn0 - haPKA + nicotinamide derivative
    
  • 6z08, 7bar - haPKA + ligand
    
  • 6yps - haPKA + inhibitor
    
  • 4ntt – mPKA (mutant) + ADP
    
  • 1bkx – mPKA + adenosine
    
  • 3o7l – mPKA + phospholamban
    
  • 1bx6, 1re8, 1rej, 1rek - mPKA + balanol analog
    
  • 8ukn – mPKA + ANP
    
• PKA catalytic subunit binary complex with peptide inhibitor
  • 3mvj, 3oog, 3poo, 3vqh, 4uj1, 4uj2, 4uj9, 4uja, 4ujb, 5bx6, 5bx7, 5izf, 5izj, 5j5x, 7ujx - hPKA + peptide inhibitor
    
  • 9dw4, 9dw5, 9dw7, 9dw8 - hPKA + CFTR peptide – Cryo EM
    
  • 4z84, 4z83 - hPKA (mutant) + peptide inhibitor
    
  • 2gfc, 3dnd, 3dne, 3kkv, 3zo1, 3zo2, 3zo3, 3zo4, 4ie9, 4ij9, 4yxs, 4yxr - bPKA + peptide inhibitor
    
  • 2gng, 4axa, 4c33, 4c34, 4c35, 4c36, 4c37, 4c38 - bPKA (mutant) + peptide inhibitor
    
  • 1cdk - pPKA + peptide inhibitor – pig
    
  • 1ctp, 1fmo, 1l3r, 1xh4, 1xh5, 1xh6, 1xh7, 1xh8, 1xh9, 1xha, 3fjq, 3x2u, 3x2v, 3x2w, 4dg0, 4dg2, 4dh1, 4dh3, 4dh5, 4dh7, 4dh8, 4hpt, 4hpu, 4xw6, 4xw5, 4xw4 – mPKA + peptide inhibitor
    
  • 1q61, 1q62, 1smh, 2qur, 3qal, 3qam, 4dfx, 4dfz, 4dg3 - mPKA (mutant) + peptide inhibitor
    
  • 4iac, 4iad, 4iaf, 4iai, 4iak, 4iay, 4iaz, 4ib0 - mPKA + PSP20 peptide
    
  • 4ib1, 4ib3, 4o22 – mPKA + SP20 peptide
    
  • 6mm5 – mPKA + ryanodine receptor 2 peptide
    
  • 6mm6, 6mm7, 6mm8 – mPKA + ryanodine receptor 2 phosphorylation domain
    
  • 4wb5, 4wb6, 4wb8 – mPKA (mutant) + PKI peptide
    
  • 4wih, 5lcp, 5lcq, 5lcr, 5lct, 5lcu, 5m0u - haPKA + peptide inhibitor
    
  • 6wjf, 6wjg - rPKA + DNAJ B1 – Cryo EM
    
• PKA catalytic subunit ternary complex
  • 2gu8, 3l9l, 3ovv, 3owp, 3oxt, 3p0m, 5uzk - hPKA catalytic subunit + peptide inhibitor + inhibitor
    
  • 3nx8 - hPKA catalytic subunit + peptide inhibitor + phenol
    
  • 3ama, 3amb, 3l9m, 3l9n - hPKA (mutant) + peptide inhibitor + inhibitor
    
  • 3wyg – hPKA + GSP1P + exportin
    
  • 6qj7 – hPKA + PKI + inhibitor
    
  • 1stc - bPKA + peptide inhibitor + saturosporine
    
  • 2gnh, 2gni, 2gnj, 2gnl, 2jdv, 2uvx, 2uvy, 2uvz, 2uw0, 2uw3, 2uw4, 2uw5, 2uw6, 2uw7, 2uw8, 2vnw, 2vny, 2vo0, 2vo3, 2vo6, 2vo7 - bPKA (mutant) + peptide inhibitor + inhibitor
    
  • 1ydr, 1yds, 1ydt, 2c1a, 2c1b, 2f7e, 2f7x, 2f7z, 2jds, 2oh0, 2ojf, 2uzt, 2uzu, 2uzv, 2uzw, 5vhb, 5vi9, 5vib, 6e99, 6e9l - bPKA + peptide inhibitor + inhibitor
  • 2gnh, 2gni, 2gnj, 2gnl, 2jdt, 2jdv, 2uvx, 2uvy, 2uvz, 2uw0, 2uw3, 2uw4, 2uw5, 2uw6, 2uw7, 2uw8, 2vnw, 2vny, 2vo0, 2vo3, 2vo6, 2vo7 - bPKA (mutant) + peptide inhibitor + inhibitor
  • 2jdt, 5vi9 - bPKA (mutant) + peptide inhibitor + inhibitor
    
  • 3e8c, 3e8e - bPKA catalytic subunit + peptide inhibitor + ATP-competitive inhibitor
    
  • 1q8t, 1q8u, 1q8w- bPKA + peptide inhibitor + rho-kinase inhibitor
    
  • 2gnf - bPKA (mutant) + peptide inhibitor + rho-kinase inhibitor
    
  • 1sve, 1svg, 1svh, 1veb - bPKA + detergent + peptide inhibitor + azepane derivative
    
  • 1cmk - pPKA + peptide inhibitor + myristic acid
    
  • 3ow3 - mPKA catalytic subunit + peptide inhibitor + inhibitor
    
  • 1apm, 1jlu - mPKA + detergent + peptide inhibitor
    
  • 2erz - mPKA + peptide inhibitor + hydroxyfasudil
    
  • 5mhi, 5n1d, 5n1e, 5n1k, 5n1l, 5n1m, 5n1n, 5n1o, 5n32, 5n33, 5n36, 5n37, 5n39, 5n3a, 5n3b, 5n3c, 5n3d, 5n3e, 5n3f, 5n7p, 5n7u - haPKA + peptide inhibitor + fragment molecule
    
  • 5ntj, 5nw8, 5o0e, 5o5m, 5ok3, 5ol3, 5ot3, 5otg, 5oua, 5ouc, 5ous, 6egw, 6eh3, 6i2b, 6i2d, 6i2h, 6ert, 6eru, 6erv, 6f14, 6frx, 6y0b, 6y2o, 6y89, 6ynr, 6yot - haPKA + peptide inhibitor + inhibitor
    
  • 5m0b, 5m0c, 5m0l, 5m6v, 5m6y, 5m71, 5m75, 6i2a, 6i2c, 6erw, 6y2u, 6yna, 6ynb, 6ync, 6ynt, 6ypp, 6yqi, 6yqj, 6yqk - haPKA + peptide inhibitor + drug
    
  • 6i2a - haPKA + RPK153 + drug
    
  • 6i2c, 6i2d - haPKA + RPK182 + drug
    
  • 7axt, 7axv, 7axw, 7baq, 7bb0, 7pid, 7pie, 7pif, 7pig, 7pih, 7pns - haPKA + PKI + ligand
    
• PKA catalytic subunit higher complex with nucleotide
  • 1q24 - bPKA + peptide inhibitor + Mg-ATP
    
  • 1jbp - mPKA + detergent + peptide inhibitor + ADP
    
  • 1rdq - mPKA + peptide inhibitor + ADP + ATP
    
  • 4o21 - mPKA + peptide inhibitor + ATP-G-S
    
  • 1atp - mPKA + peptide inhibitor + Mn-ATP
    
  • 6e21, 7v0g - mPKA + peptide inhibitor + ADP
    
  • 8uko, 8ukp – mPKA + Ca channel peptide + ANP
    
  • 7e0z, 7e11, 7e12 - mPKA + PLN peptide + PPNP
    
  • 6em7, 6em6 - haPKA + peptide inhibitor + inhibitor + ADP
    
  • 6eh2 - haPKA + peptide inhibitor + inhibitor + AMP
    
  • 6esa - haPKA + peptide inhibitor + ribose + AMP
    
  • 6ema - haPKA + peptide inhibitor + inhibitor + ATP
    
  • 6y8c – haPKA + PKI peptide + ATP
    
  • 6y05 – haPKA + PKI peptide + Adenine
    
• PKA regulatory subunit

• • 4f9k – hPKA I-β
    
  • 1ne4, 1ne6, 1rl3, 3iia, 1rgs, 4mx3 - bPKA
    
  • 2ezw - bPKA I-α dimerization-anchoring domain - NMR
    
  • 3im3 - bPKA I-α dimerization-anchoring domain
    
  • 3pna - bPKA I-α cAMP-binding domain
    
  • 1cx4 - rPKA II-β cAMP-binding domain – rat
    
  • 1r2a - mPKA II dimerization-anchoring domain – NMR
    
  • 1l6e - mPKA II-α dimerization-anchoring domain – NMR
    
  • 3of1, 6xqk - yPKA
    

• PKA regulatory subunit binary complex

• • 5kjx - hPKA I-α + cAMP
    
  • 5kjy, 5kjz - hPKA I-α (mutant) + cAMP
    
  • 2izx, 2izy, 4zp3 - hPKA II-α + A-kinase anchoring protein peptide
  • 2kyg - hPKA II-α + CBFA2T1
  • 8s8o - hPKA II-α + microtubule-associated protein 2 80-120 - NMR
  • 3im4, 5hvz - bPKA I-α + A-kinase anchoring protein peptide
    
  • 4jv4 – bPKA I-α + cAMP analog
    
  • 3plq - bPKA I-α + cAMP derivative
    
  • 2hwn - rPKA II-α + A-kinase binding peptide
    
  • 4jva – rPKA II-β + cAMP analog
    
  • 2drn, 2h9r - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide – NMR
    
  • 5t3n - PfPKA + cAMP derivative – Plasmodium falciparum
    
  • 5kbf, 5k8s - PfPKA + cAMP
    
  • 6h4g - PKA (mutant) + cAMP – Trypanosoma brucei
    
  • 6rsx - PKA + cAMP – Euglena gracilis
    
• PKA regulatory subunit ternary complex
  • 3tmh - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide + NHERF-3
    
  • 8em8 - PfPKA + peptide + inhibitor
    
• PKA catalytic and regulatory subunits
  • 6bys, 6no7 – hPKA
    
  • 2qvs, 3idb, 3idc, 3pvb, 4din, 4x6q, 4wbb - mPKA
    
  • 3fhi, 2qcs, 3tnp, 3tnq, 4x6r - mPKA (mutant)
    
  • 3j4q, 3j4r – mPKA + A-kinase anchor protein 18
    
  • 5jr7 – m+bPKA + ADP