Cell death protein

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Cell death proteins or Programmed cell death protein or CD279 (CED) are involved in the process of cellular apoptosis.

  • CED-1 is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. [1] CED-1 and CED-L1 complex with glycerol</scene> (3bik).
  • CED-3 is a cysteine protease involved in apoptosis[2].
  • CED-4 attenuates tumorigenesis by translational contro[3]. lFor details on CED-4 see CED-4 Apoptosome. <scene name='50/507728/Cv/2'>[4].
  • CED-5 can accelerate apoptosis in different kinds of cells in response to different stimuli[5].
  • For details on CED-8 see Apoptosis-inducing factor.

Cell death protein 3D structures

Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code 3bik)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Domling A, Dubin G, Holak TA. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Structure. 2015 Oct 22. pii: S0969-2126(15)00402-5. doi:, 10.1016/j.str.2015.09.010. PMID:26602187 doi:http://dx.doi.org/10.1016/j.str.2015.09.010
  2. ↑ Xue D, Shaham S, Horvitz HR. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes Dev. 1996 May 1;10(9):1073-83. PMID:8654923 doi:10.1101/gad.10.9.1073
  3. ↑ Wang Q, Yang HS. The role of Pdcd4 in tumour suppression and protein translation. Biol Cell. 2018 May 28:10.1111/boc.201800014. PMID:29806708 doi:10.1111/boc.201800014
  4. ↑ Lin DY, Tanaka Y, Iwasaki M, Gittis AG, Su HP, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi DN. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3011-6. Epub 2008 Feb 14. PMID:18287011
  5. ↑ Malottki K, Popat S, Deeks JJ, Riley RD, Nicholson AG, Billingham L. Problems of variable biomarker evaluation in stratified medicine research--A case study of ERCC1 in non-small-cell lung cancer. Lung Cancer. 2016 Feb;92:1-7. PMID:26775588 doi:10.1016/j.lungcan.2015.11.017

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