Nonstructural protein 3D structures

3D Structures of Nonstructural protein3D Structures of Nonstructural protein

Updated on 03-April-2024

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• Nonstructural protein
  • 3o9q, 4opa, 4oph, 6nrl, 6o01, 6oqe – IvNS1 (mutant) – Influenza virus
    
  • 3o9r, 3o9s, 3o9t, 3o9u, 3f5t – IvNS1
    
  • 3m8a, 2z0a, 1xeq, 1ail, 6sw8 – IvNS1 RNA-binding domain 2-73
    
  • 1ns1 - IvNS1 RNA-binding domain - NMR
    
  • 3p31 – IvNS1 C terminal effector domain
    
  • 3p38, 3p39 – IvNS1 C terminal effector domain (mutant)
    
  • 3m5r, 2gx9 - IvNS1 effector domain
    
  • 6nu0 - IvNS1 effector domain 1-230 – NMR
    
  • 6dgn - IvNS1 effector domain (mutant) 86-205
    
  • 1pd3 – IvNS2 M1-binding domain
    
  • 3l6p, 3lkw – DvNS2B/3 protease domain (mutant) – Dengue virus
    
  • 2o1j – RvNSP4 diarrhea-inducing domain – Human rotavirus
    
  • 2gu0, 6auk, 6cy9, 7kpo, 7kpp – RvNS2
    
  • 5y2h, 5y2j, 5y9r – RvNSP4 diarrhea-inducing domain – bovine rotavirus
    
  • 2ajj, 2ajm, 2ajn, 2ajo – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR
    
  • 1fw5 – NS1 membrane-binding domain – Semliki forest virus – NMR
    
  • 5vj2 – HrsvNS1 – Human respiratory syncytial virus
    
  • 7ldk – HrsvNS2
    
  • 5i65 – NS ORF1A – porcine reproductive and respiratory syndrome virus
    
  • 6lpa – pcvNS1 – porcine corona virus
    
  • 6ln0 – pcvNS3
    
  • 6mwm – NS3 – bat corona virus - NMR
    
  • 1qol – NSP20A (mutant) - Foot-and-mouth disease virus
    
  • 1nhu – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus
    
  • 1r7c, 1r7d, 1r7e, 1r7f, 1r7g - HvNS5A membrane-anchor domain - NMR
    
  • 8a55 – SvNS1 N-terminal 11-125 – Sars coronavirus
    
  • 7eq4 – SvNS1 N-terminal 11-125 (mutant)
    
  • 2gdt, 2hsx – SvNS1 N-terminal (mutant) – NMR
    
  • 7ci3, 7lhq – SvNS7A
    
  • 7bwq – SvNS9
    
  • 2l8k – NS7 residues 1454-1575 – Arterivirus - NMR
    
  • 3mtv – PrrsvNS1 residues 181-383 – PRRS virus
    
  • 6jdr, 6jds, 6jdu – PrrsvNS10
    
  • 3zfn, 3zfo, 3zfq, 3zfp, 3zfr, 3zft, 3zfu – Npro (mutant) – Pestivirus
    
  • 4r05 – DvNS5 residues 2491-2752
    
  • 4x2z – NS3 residues 1174-1483 – Avian infectious bronchitis virus
    
  • 4cbg, 4cbh, 4cbl, 4cbm – NS3 – Swine fever virus
    
  • 2hwk – VeevNS2 – Venzuelan equine encephalitis virus
    
  • 8duf – VeevNS2 (mutant)
    
  • 6lp9 – fipvNSP1 – Feline infectious peritonitis virus
    
  • 3ub0 – fipvNSP6 + NSP7
    
  • 6ivc – tgvNSP1 – transmissible gastroenteritis virus
    
  • 6ivd – tgvNSP1 (mutant)
    
  • 6n9y – NS1 – Bluetongue virus
    
  • 6vdo – HcvNS3 (mutant) – Hepacivirus C
    
  • 7oj4, 7jno – NS3 helicase domain – Tick-borne encephalitis virus
    
  • 7dop – CvNS1 – Chicungunya virus - Cryo EM
    
• For Zika virus nonstructural proteins NS2B and NS3 see Virus protease
• Nonstructural protein complex
  • 6weq, 6wer, 7bsc – DvNS1 + antibody
    
  • 7k93 – DvNS1 + scFv
    
  • 2xbm – DvNS5 methyltransferase domain + RNA
    
  • 3p8z - DvNS5 methyltransferase domain + SAH + inhibitor
    
  • 5cuq - DvNS5 methyltransferase domain + inhibitor
    
  • 5fc8 - DvNS5 C-terminal + importin
    
  • 2hye – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5
    
  • 2b5l - SvNSV + DNA damage-binding protein
    
  • 7t70, 7t8m, 7t8r, 7t9y, 7ta4, 7ta7, 7tb2, 7tbt, 7tc4 - SvNSV + 3C-like proteinase
    
  • 1nhv – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor
    
  • 1dxp, 1dy8, 1dy9, 1w3c – HvNS4A + HvHelicase NS3
    
  • 4k8b - HvNS4A + HvProtease NS3 + inhibitor
    
  • 4a1t, 4a1x - HvNS4A + peptide inhibitor
    
  • 3phe– HvNS5B + quinolone derivative
    
  • 6w4g – HvNS5B 2421-2981 + inhibitor
    
  • 1knz – RvNSP34 N terminal + mRNA
    
  • 1lj2 – RvNSP34 C terminal + eukaryotic protein synthesis initiation factor peptide
    
  • 4r8r – DvNS5 residues 2491-2752 + adenosyl-Met
    
  • 4r8s – DvNS5 residues 2491-2752 + sinefungin
    
  • 6ux2 – ZvNS5 residues 2789-3419 + P113 - Zika virus
    
  • 6wcz – ZvNS5 + hSTAT2
    
  • 6i7p – ZvNS5 + SAH
    
  • 7x01 – CvNS1 + inhibitor – Cryo EM
    
  • 6jim – CvNS2 + RNA
    
  • 7fgg, 7fgh, 7fgi – CvNS1 + nucleotide – Cryo EM
    
  • 6jim – NS2 + RNA – Chicungunya virus
    
  • 6usm – NS1 + MBP – Human parvovirus
    
  • 6sx0, 6zlc – IvNS1 RNA-binding domain + RNA
    
  • 6sx2 – IvNS1 RNA-binding domain (mutant) + RNA
    
  • 6e5u – IvNS1 + NXF1 + NXT1
    
  • 6mvo – HcvNS5B + inhibitor
    
  • 6qsn – NS5A + SAH – yellow fever virus
    
• Nonstructural protein NS3 from SARS CoV-2; Domain 1564-1878 (papain-like protease), [[3241-3546 (3C-like proteinase) see Virus protease 3D structures
  • 2jzd, 2jze, 2jzf, 2rnk – SvNS3 residues 527-651 – NMR
    
  • 7kag – Sv2NS3 Ubl1 domain 819-929
    
  • 6vxs, 6wcf, 6wen, 6wey, 6ywk, 6ywm, 7kg3, 7kqo, 7kqw, 7kr0, 7kr1 – Sv2NS3 macrodomain 1025-1191
    
  • 2kaf - SvNS3 residues 1473-1532 – NMR
    
  • 7lgo – Sv2NS3 NAB domain 1907-2021
    
  • 7rqg – Sv2NS3 Y3 domain 2662-2763
    
  • 7kxb, 7lg7 – Sv2NS3 macrodomain + inhibitor
    
  • 6w02, 6woj, 6ywl, 7bf5, 7c33, 7cz4, 7kqp – Sv2NS3 macrodomain + ADP-ribose
    
  • 6w6y, 7nme – Sv2NS3 macrodomain + cyclic AMP
    **
  • 7bf4 – Sv2NS3 macrodomain + GMP
    
  • 7bf3 – Sv2NS3 macrodomain + adenosine
    
  • 7bf6 – Sv2NS3 macrodomain + drug
    
  • 6yxj – Sv2NS3 macrodomain II 1207-1344 + Paip1
    
• Other nonstructural protein from SARS CoV-2; SV2NS14 is proofreading exoribonuclease
  • 6zlw, 6zoj, 6zok, 6zol, 7k5i – Sv2NS1 in human 40S ribosome – Cryo EM
    
  • 6zmt, 6zn5 – Sv2NS1 in human pre-40S-like ribosome – Cryo EM
    
  • 6zp4, 6zon – Sv2NS1 in human 43S ribosome – Cryo EM
    
  • 6zm7, 6zme, 6zmi, 6zmo – Sv2NS1 in human 80S ribosome – Cryo EM
    
  • 7jqb, 7jqc – Sv2NS1 in rabbit 40S ribosome – Cryo EM
    
  • 7opl – Sv2NS1 13-127 + DNA polymerase + DNA primase – Cryo EM
    
  • 7k7p – Sv2NS1 1-180
    
  • 7msw, 7msx – Sv2NS2 – Cryo EM
    
  • 7exm – Sv2NS2 181-456
    
  • 2kys – Sv2NS7 3837-3919 – NMR
    
  • 7jtl – Sv2NS8 residues 18-121
    
  • 6w4b, 6wc1, 6wrb, 6wxd – Sv2NS9 residues 4141-4235
    
  • 6zct, 6zpe, 7nts – Sv2NS10 residues 4263-4384
    
  • 7orr, 7oru, 7orv, 7orw – Sv2NS10 residues 4263-4384 + imidazole derivative
    
  • 6z6i – Sv2NS10 residues 1024-1197 + ADP derivative
    
  • 5f22, 6m5i, 6wiq, 6wqd, 6wtc, 6xip, 6yhu, 7dcd, 7jlt – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134
    
  • 6m71, 7btf, 7bv1, 7bw4, 7d4f – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 – Cryo EM
    
  • 6nur, 6nus – Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 – Cryo EM
    
  • 5rob, 6jyt, 6zsl, 7nio – SvNS13
    
  • 5smk, 7qgi – proofreading exoribonuclease
    
  • 7diy – proofreading exoribonuclease residues 5926-6214 + Sv2NS10 residues 4254-4392
    
  • 6vww, 6w01, 6xdh, 7kf4 – Sv2NS15 residues 6453-6798
    
  • 6w4h – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392
    
• Other nonstructural protein from SARS CoV-2 complexes
  • 7ozu, 7ozv – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + RNA + replicase polyprotein – Cryo EM
    
  • 6xqb, 6yyt, 7bzf, 7c2k, 7cyq, [[[7dte]], [7krn]], 7kro, 7krp, 7l1f, 7oyg – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA – Cryo EM
    
  • 7aap, 7b3b, 7b3c, 7bv2, 7ctt, 7dfg, 7dfh – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + drug – Cryo EM
    
  • 7b3d – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + AMP – Cryo EM
    
  • 7rdx, 7rdz, 7re3 – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + ADP + helicase – Cryo EM
    
  • 6xez, 7cxm, 7cxn, 7cyq – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + Sv2NS13 residues 5325-5925 + RNA – Cryo EM
    
  • 7n3k – Sv2NS9 residues 4141-4253 + drug
    
  • 7kri – Sv2NS9 residues 4141-4253 + pyrimidine derivative
    
  • 7mc5, 7mc6 – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease
    
  • 7r2v – proofreading exoribonuclease + SAH
    
  • 7qif – proofreading exoribonuclease + MeGpppG
    
  • 5skw, 5skx, 5sky, 5skz, 5sl0, 5sl1, 5sl2, 5sl3, 5sl4, 5sl5, 5sl6, 5sl7, 5sl8, 5sl9, 5sla, 5slb, 5slc, 5sld, 5sle, 5slf, 5slg, 5slh, 5sli, 5slj, 5slk, 5sll, 5slm, 5sln, 5slo, 5slp, 5slq, 5slr, 5sls, 5slt, 5slu 5slv, 5slw, 5slx, 5sly, 5slz, 5sm0 5sm1, 5sm2, 5sm3 5sm4, 5sm5, [[[5sm6]] 5sm7, 5sm8, [5sm9]] 5sma, [[5smib], 5smc 5smd, 5sme, 5smf, 5smg 5smh, 5smi, 5smk – proofreading exoribonuclease + inhibitor
    
  • 7n0b, 7n0c, 7n0d – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease + RNA – Cryo EM
    
  • 5rl6, 5rl7, 5rl8, 5rl9, 5rlc, 5rld, 5rle, 5rlf, 5rlg, 5rlh, 5rli, 5rlj, 5rlk, 5rll, 5rlm, 5rln, 5rlo, 5rlp, 5rlq, 5rlr, 5rls, 5rlt, 5rlu, 5rlv, 5rlw, 5rly, 5rlz, 5rm0, 5rm1, 5rm2, 5rm3, 5rm4, 5rm5, 5rm6, 5rm7, 5rm8, 5rm9, 5rma, 5rmb, 5rmc, 5rmd, 5rme, 5rmf, 5rmg, 5rmh, 5rmi, 5rmj, 5rmk 5rml, 5rmm, 7nng – SvNS13 + inhibitor
    
  • 7nn0 – SvNS13 + AMPPNP
    
  • [6wlc]], 6x4i, 7k1l – Sv2NS15 residues 6453-6798 + uridine derivative
    
  • 6wxc – Sv2NS15 residues 6453-6798 + drug
    
  • 6w61, 6w75, 6wvn, 6xkm, 7bq7, 7c2i, 7c2j, 7jpe, 7koa – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM
    
  • 6wjt, 6wq3, 6wrz, 7jhe, 7lw3, 7lw4 – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH
    
  • 7jib – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH + SAM
    
  • 7jyy – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM + RNA
    
  • 6wks – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM + GpppA
    
  • 7jz0, 7l6r, 7l6t – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH + RNA
    
  • 6wkq, 6yz1 – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + sinefungin
    
  • 6yyt – Sv2NS12 residues 4393-5324 + Sv2NS8 residues 3943-4140 + Sv2NS7 residues 3860-3942 + RNA