Crystal Structure of Human Rotavirus NSP2 (Group C / Bristol Strain)Crystal Structure of Human Rotavirus NSP2 (Group C / Bristol Strain)
Structural highlights
2gu0 is a 2 chain structure with sequence from Human rotavirus C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NSP2_ROTHC Involved in genome replication and packaging. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where replication intermediates are assembled and RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activity activities. The unwiding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. Unlike typical helicases, NSP2 requires neither a divalent cation nor a nucleotide energy source for helix destabilization. The RTPase activity may account for the absence of the 5'-terminal gamma-phosphate on the minus-strands of dsRNA genome segments (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
