8e22

VPS37A_21-148VPS37A_21-148

Structural highlights

8e22 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

VP37A_HUMAN Autosomal recessive spastic paraplegia type 53. The disease is caused by variants affecting the gene represented in this entry.

Function

VP37A_HUMAN Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.^[1]

References

↑ Bache KG, Slagsvold T, Cabezas A, Rosendal KR, Raiborg C, Stenmark H. The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell. 2004 Sep;15(9):4337-46. PMID:15240819 doi:10.1091/mbc.e04-03-0250

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OCA

[1] Bache KG, Slagsvold T, Cabezas A, Rosendal KR, Raiborg C, Stenmark H. The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell. 2004 Sep;15(9):4337-46. PMID:15240819 doi:10.1091/mbc.e04-03-0250

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