Structure of the multifunctional paramyxovirus hemagglutinin-neuraminidaseStructure of the multifunctional paramyxovirus hemagglutinin-neuraminidase
Structural highlights
1e8u is a 2 chain structure with sequence from Avian orthoavulavirus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
HN_NDVK Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
