FunctionThe portal protein (PP) is a key component during viral chromosomal packaging. PPs have a central channel through which DNA movements occur. PPs are proposed to be the mechanical device that pumps DNA to the interior of the viral capsid[1]. The DNA translocation motor is composed of PP and of the the viral ATPase that fuels DNA translocation. The PP has an active control over the viral ATPase activity[2].
3D Structures of portal proteinPortal protein 3D structures
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3D Structures of portal protein3D Structures of portal protein
Updated on 05-September-2023
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- Portal protein
- 2jes – Spp1Gp6 – Bacteriophage Spp1
- 3lj5, 5jj1, 5jj3 – P22Gp1 – Bacteriophage P22
- 6qx7, 6qyj, 6qym – P29PP – Bacteriophage P29 – Cryo EM
- 6qwp, 6qx5, 6tjp – T7PP – Bacteriophage T7
- 6qxm, 7bou, 7bp0, 7ey6, 7ey8 – T7PP – Cryo EM
- 6qx7, 6qyj, 6qym – BpPP – Bacteriophage φ29 – Cryo EM
- 4zjn, 6ibg – G20CPP – Bacteriophage G20C
- 5ngd – G20CPP (mutant)
- 3ja7 – T4Gp20 – Bacteriophage T4 – Cryo EM
- 6qjt – P23 – Thermus virus – Cryo EM
- 3kdr – HK97 – Corynebacterium diphtheriae
- 6od7 – PP – human herpesvirus 1 – Cryo EM
- 6rvr, 6rvs, 7bqt – PP – human herpesvirus 4 – Cryo EM
- 7et2, 7etm – PP – human herpesvirus 5 – Cryo EM
- 6ppi – PP – human herpesvirus 8 – Cryo EM
- 6qjt – PP – Thermus virus – Cryo EM
- Portal protein complexes
- 5a21, 5a20 – Spp1Gp6 + Gp15 + Gp16 + Gp17 – Cryo EM
- 4v4k – P22Gp1 + Gp4
- 5gai – P22Gp1 + Gp4 + Gp6 – Cryo EM
- 6iac – PP + lower collar protein + minor structural protein + inner core protein – Staphylococcus phage P68 – Cryo EM
- 6qz9, 6qzf – BpPP + neck appendage protein + tail tube protein – Cryo EM
- 6iac – PP + lower collar protein + minor structural protein + inner core protein - Staphylococcus phage P68 – Cryo EM
- 6tba, 6te8, 6te9, 6to8, 6toa, 6tui – PP in GTA particle – rhodobacter capsulatus – Cryo EM
- 6uzc – T4PP + major capsid protein – Cryo EM
- 6r21 – T7PP in tail complex – Cryo EM
- 7kln – PP + Gp1 – Vibrio phage XM1 - Cryo EM
ReferencesReferences
- ↑ Isidro A, Henriques AO, Tavares P. The portal protein plays essential roles at different steps of the SPP1 DNA packaging process. Virology. 2004 May 1;322(2):253-63. doi: 10.1016/j.virol.2004.02.012. PMID:15110523 doi:http://dx.doi.org/10.1016/j.virol.2004.02.012
- ↑ Oliveira L, Henriques AO, Tavares P. Modulation of the viral ATPase activity by the portal protein correlates with DNA packaging efficiency. J Biol Chem. 2006 Aug 4;281(31):21914-23. doi: 10.1074/jbc.M603314200. Epub 2006 , May 30. PMID:16735502 doi:http://dx.doi.org/10.1074/jbc.M603314200
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