Nitric Oxide Synthase 3D structures

Endothelial NOS; Domains – PDZ – 1-130; oxygenase (OD) 66-492; heme – 302-722; FAD/NADP – 963-1397

Endothelial NOS oxygenase domain (OD) 66-492

3nos, 4d1o – h-eNOS OD+arginine - human
1m9j – h-eNOS OD+chlorzoxazone
1m9k, 1m9r, 4d1p, 6av7, 6av6, 6nhf, 6nh8, 6nh7, 6nh6, 6nh5, 6nh4, 6nh3, 6nh2, 6nh1, 6cif, 6cie, 3eah – h-eNOS OD+ inhibitor
1nsi - h-eNOS OD+ Zn
3nld, 3nle, 3nlf, 3nlg, 3jww, 3jwx, 3jwy, 3jwz, 3dqs, 3dqt, 3pnh, 4luw – b-eNOS OD+ pyridine derivative – bovine
1dm6 – b-eNOS OD+guanidine derivative
3nlh, 3rqo, 3rqp – b-eNOS OD (mutant)+ pyridine derivative
1rs8, 1rs9, 1p6n – b-eNOS OD +dipeptide inhibitor
1nse – b-eNOS OD
5nse, 1fol, 1foo, 1fop, 1dm7, 2nse, 3nse, 4nse – b-eNOS OD+arginine derivative
7nse – b-eNOS OD+ADMA
1d1v, 1d1x, 1d1y, 1ed4, 9nse – b-eNOS OD+urea derivative
1dmj, 1dmk – b-eNOS OD+pterin derivative
1foi, 1dmi, 1i83, 3n5p, 3n5q, 3n5r, 3n5s, 3n5t, 3n5v, 3n5w, 3n5x, 3n5y, 3n5z, 3n60, 3n61, 3n62, 3n63, 3n64, 3n65, 3n66, 3n67, 3n68, 3n69, 3n6a, 3n6b, 3n6c, 3n6d, 3n6e, 3n6f, 3n6g, 3nlt, 3nlu, 3e7s, 5vv6, 5vv7, 5vv8, 4upq, 4upr, 4ups, 4upt, 5vva, 5vvb, 5vvc, 5vvd, 5vvg, 5vvn, 5uo8, 5uo9, 5uoa, 5uob, 5uoc, 5uod, 5fvy, 5fvz, 5fj2, 5fj3, 5adj, 5adk, 5adl, 5adm, 5adn, 4d33, 4d34, 4d35, 4d36, 4d37, 4d38, 4d39, 4d3a, 4cul, 4cum, 4cun, 4cvg, 4cwv, 4cww, 4cwx, 4cwy, 4cty, 4ctz, 4cu0, 4cu1, 5vv9 – b-eNOS OD+inhibitor
4cwz, 4cx0, 4cx1, 4cx2 – b-eNOS OD (mutant) +inhibitor
1d0c, 8nse, 1foj, 1ed5, 1d0o, 1d1w – b-eNOS OD+indazole derivative
1dm8 – b-eNOS OD+triazole derivative
1ed6 – b-eNOS OD+NO

Endothelial NOS heme domain

6pou, 6pov, 6pow, 6pox, 6poy, 6poz, 6pp0, 6pp1, 6pp2, 6pp3, 6pp4, 7m56, 7tsg, 7tsh, 7tsi, 7tsk, 7tsl, 7tsm, 7tsn, 7tso, 7tsp, 7uao – h-eNOS heme domain + inhibitor
6ng1, 6ng2, 6ng4, 6ng5, 6ng6, 6ng7, 6ng8, 6nga, 6ngb, 6ngc, 6ngd, 6nge, 6ngf, 6ngh, 6ngi – h-eNOS heme domain (mutant) + inhibitor
1q2o – b-eNOS OD (mutant)+dipeptide inhibitor
6nse - b-nNOS heme domain + canavanine
1p6l, 1p6m – r-eNOS OD +dipeptide inhibitor – rat
4jsk, 4jsl, 4jsm, 4imx, 4k5h, 4k5i, 4k5j, 4k5k, 4c3a – r-eNOS OD+ pyridine derivative
4kcp, 4kcq, 4kcr, 4kcs - r-eNOS OD +thiophene carboximidamide derivative
4uh0, 4uh1, 4uh2, 4uh3, 4uh4, 4uh7, 4uh8, 4uh9, 4uha, 6ngj, 6ngk, 6ngl, 6ngm, 6ngn, 6ngp, 6ngq, 6ngr, 6ngs, 6ngt, 6ngu, 6ngv, 6ngw, 6ngx, 6ngy, 6ngz, 6nh0 – r-eNOS heme domain + inhibitor

Neuronal NOS; heme domain 297-718

4uh5, 6av5, 6av4, 6av3, 7ts8, 7tsf - h-nNOS heme domain +inhibitor
4uh6, 4uch, 6av2, 6av1, 6av0, 6auz, 6auy, 5vv4, 5vv2, 5vv1, 5vuz, 5vuy, 5vux, 5vuw, 5vuv, 6nhb, 6nhc, 6cid, 6ng8, 6ngi, 6ngh, 6ngf, 6nge, 6ngd, 6ngc, 6ngb, 6nga, 6ng7, 6ng6, 6ng5, 6ng4, 6ng2, 6ng1, 6cic, 6nhb, 6nhc, 6pna, 6pnb, 6pnc, 6pnd, 6pne, 6pnf, 6png, 6pnh, 6po5, 6po7, 6po8, 6po9, 6poa, 6pob, 6poc, 6pot, 7ts1, 7ts2, 7ts3, 7ts4, 7ts5, 7ts6, 7ts6, 7uam, 7us7, 7us8 - h-nNOS heme domain (mutant) +inhibitor
4d1n - h-nNOS heme domain (mutant) + arginine
4cam, 4can, 4cao, 4cap, 4caq, 4car, 4cdt, 4cft – r-nNOS heme domain + quinoline derivative
4kch, 4kci, 4kcj, 4kck, 4kcl, 4kcm, 4kcn, 4kco - r-nNOS heme domain +thiophene carboximidamide derivative
6nhd, 6nhe, 6pmv, 6pmw, 6pmx, 6pmy, 6pmz, 6pn0, 6pn1, 6pn2, 6pn3, 6pn4, 6pn5, 6pn6, 6pn7, 6pn8, 6pn9, 7s3x, 7s3y, 7s3z, 7s40 - r-nNOS heme domain +inhibitor
7ts9, 7tsa, 7tsb, 7tsc, 7tsd, 7tse, 7uan - r-nNOS heme domain (mutant) + inhibitor

Neuronal NOS; oxygenase domain (OD) 297-718

2hx2 – b-nNOS OD+nitroguanidine derivative
3nlv, 3nlw, 3nlx, 3nly, 3nlz, 3nm0 - b-nNOS OD + inhibitor
3nlj, 3nlk, 3nln, 3nlo, 3nlp, 3nlq, 3nlr, 3jws, 3jwt, 3jwu, 3jwv, 3jx0, 3jx1, 3jx2, 3jx3, 3jx4, 3jx5, 3jx6, 3pne, 3pnf, 3png, 3svp, 3svq – r-nNOS OD (mutant)+pyridine derivative
3nlm, 3nny, 3nnz, 3n2r, 3b3o, 3b3p, 3b3m, 3b3n, 3rqj, 3rqk, 3rql, 3rqm, 3rqn, 3tyl, 3tym, 3tyn, 3tyo, 4ims, 4imt, 4imu, 4imw, 4jse, 4jsf, 4jsg, 4jsh, 4jsi, 4jsj, 4k5d, 4k5e, 4k5f, 4k5g, 4lux – r-nNOS OD+ pyridine derivative
1om4, 1k2r, 1k2s, 1lzx, 2hx4, 1zvl, 1qw6, 4fvw, 4fvx, 4fvy, 4fvz, 4fw0 – r-nNOS OD+arginine derivative
4gqe – r-nNOS OD + norvaline derivative
1k2t, 1k2u – r-nNOS OD+thiourea derivative
1om5 – r-nNOS OD+indazole derivative
1lzz, 1m00, 2hx3 – r-nNOS OD+guanidine derivative
3fc5, 1zvi – r-nNOS OD
1qwc, 3q99, 3q9a, 1mmv, 1mmw, 3dqr, 3ufo, 3ufp, 3ufq, 3ufr, 3ufs, 3uft, 3ufu, 3ufv, 3ufw, 4eux, 5vui, 4upm, 4upn, 4upo, 4upp, 5vuk, 5vul, 5vum, 5vun, 5vuo, 5vup, 5vuq, 5vur, 5vus, 5vut, 5vuu, 5unr, 5unt, 5unu, 5unv, 5unw, 5unx, 5uny, 5unz, 5uo0, 5fw0, 5fvo, 5fvp, 5fvq, 5fvr, 5fvs, 5fvt, 5agk, 5agl, 5agm, 5agn, 5ago, 5agp, 4v3v, 4v3w, 4v3x, 4v3y, 4v3z, 5ad4, 5ad5, 5ad6, 5ad7, 5ad8, 5ad9, 5ada, 5adb, 5adc, 4ugz, 4d33, 4d34, 4d35, 4d2y, 4d1z, 4d30, 4d31, 4d7o, 4d3b, 4d32, 4ctp, 4ctq, 4ctr, 4ctt, 4ctu, 4ctv, 4c39, 6aux, 6auw, 6auv, 6auu, 6aut, 6aur, 6auq, 5vuj, 4d2z, 4ctx, 4ctw, 6nhe, 6nhd, 6nh0, 6ngz, 6ngy, 6ngx, 6ngw, 6ngv, 6ngu, 6ngt, 6ngs, 6ngr, 6ngq, 6ngp, 6ngn, 6ngm, 6ngl, 6ngk, 6ngj, 7tsf – r-nNOS OD+inhibitor
5vv0, 5vv3, 5vv5, 5uns, 5uo1, 5uo2, 5uo3, 5uo4, 5uo5, 5uo6, 5uo7, 5g0n, 5g0p, 5fvu, 5fvv, 5fvx, 5fvw, 4v3u, 5add, 5ade, 5adf, 5adg, 5adi, 4cx3, 4cx4, 4cx5, 4cx6, 6aus, 5g0o – r-nNOS OD (mutant) +inhibitor
3jt3, 3jt4, 3jt5, 3jt6, 3jt7, 3jt8, 3jt9, 3jta – r-nNOS OD+ornithine derivative
3hsn – r-nNOS OD+NHA+CO
3hso, 3hsp - r-nNOS OD+NHA+NO
2g6h, 2g6i, 2g6j – r-nNOS OD+pterin derivative
2g6k, 2g6l – r-nNOS OD+pterin derivative+NO
2g6m, 2g6n, 2g6o – r-nNOS OD+pterin derivative+CO
1zzq, 1zzr, 1zzs, 1zzt, 1zzu, 1p6k – r-nNOS OD (mutant)+dipeptide inhibitor
1rs6, 1rs7, 1p6h, 1p6i, 1p6j – r-nNOS OD +dipeptide inhibitor
1vag – m-nNOS OD+inhibitor – mouse

Neuronal NOS; other domains

1qau - r-nNOS PDZ domain
1qav, 4hop - r-nNOS PDZ domain + α-1 syntrophin
1b8q – r-nNOS PDZ domain + heptapeptide
1f20 - r-nNOS FAD/NADP domain
1tll – r-nNOS resdues 742-1429

Inducible NOS

3hr4 – h-iNOS residues 503-715+calmodulin
4nos, 4cx7, 3e7g, 3ej8 – h-iNOS OD+inhibitor
4nsi – h-iNOS OD+arginine
2nsi – h-iNOS OD+thiourea derivative
6key - h-iNOS OD + SOCS box protein
3nqs, 3e65, 3eai, 3ebd, 3ebf, 1r35, 2nod – m-iNOS OD + pterin derivative
1jwj, 1jwk – m-iNOS OD (mutant)+ pterin derivative
4ux6 – m-iNOS OD + pterin derivative + inhibitor
2bhj – m-iNOS OD+coumarin
3nod – m-iNOS OD+product analog
1noc – m-iNOS OD+chloramphenicol acetyltransferase
3e67 – m-iNOS OD+4-MAP
3e68, 3e6l, 3e6n, 3e6o, 3e6t, 3e7i, 3e7m, 3e7t, 1vaf, 1qw5, 1dd7, 2y37 – m-iNOS OD+inhibitor
2orq, 2orr, 2ors, 2ort, 2oro, 2orp, 1nos, 3nw2 – m-iNOS OD+imidazole derivative
1df1 - m-iNOS OD+ urea derivative
3dwj – m-iNOS OD (mutant)
1qom, 4js9 - m-iNOS OD
1qw4, 1dwv, 1dww, 1dwx, 1nod – m-iNOS OD+arginine derivative
2nos – m-iNOS OD+guanidine derivative
1n2n – m-iNOS OD+CN
1m9t – m-iNOS OD+indazole derivative
1m8d – m-iNOS OD+chlorzoxazone
1m8e, 1m8h, 1m8i, 1m9m, 1m9q – m-iNOS OD+ indazole derivative
3gof - c-iNOS OD + calmodulin – chicken

Prokaryote NOS

2amo – BsNOS – Bacillus subtilis
2an0, 2an2 – BsNOS (mutant)
2fbz, 2fc2, 2fc1 – BsNOS+NO
1m7v, 1m7z – BsNOS+THF+arginine
6xcx, 6xk3, 6xk4, 6xk5, 6xk6, [[[6xk7]], [6xk8]], 6xmc – BsNOS + inhibitor
5g67, 5g6q, 5g6p, 5g6o, 5g6n, 5g6m, 5g6l, 5g6k, 5g6j, 5g6i, 5g6h, 5g6g, 5g6f, 5g6e, 5g6d, 5g6c, 5g6b, 5g6a, 5g69, 5g68, 5g66, 5g65, 4ugl, 4uqs, 4uqr, 4ugy, 4ugx, 4ugw, 4ugv, 4ugu, 4ugt, 4ugs, 4ugr, 4ugq, 4ugp, 4ugo, 4ugn, 4ugm, 4ugk, 4ugj, 4ugi, 4ugh, 4ugg, 4ugf, 4uge, 4ugd, 4ugc, 4ugb, 4uga, 4ug9, 4ug8, 4ug7, 4ug6, 4ug5, 4lwb, 4lwa, 4d7j, 4d7i, 4d7h, 4d3v, 4d3u, 4d3t, 4d3o, 4d3n, 4d3m, 4d3k, 4d3j, 4d3i – BsNOS (mutant) + inhibitor
2flq – NOS+arginine – Geobacillus stearothermophilus

3D Structures of Nitric Oxide Synthase3D Structures of Nitric Oxide Synthase

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