Mitogen-activated protein kinase kinase 3D structures

3D Structures of Mitogen-activated protein kinase kinase3D Structures of Mitogen-activated protein kinase kinase

Updated on 02-July-2023

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• MAP2K1 or Mek1; Domains – PB1 2-124; kinase 62-393; TOG 548-867
  • 3mbl, 3e8n, 3dy7, 3eqb, 2p55, 4ark – hMAP2K1 kinase domain +MgADP+ligand - human
    
  • 6nyb, 6q0j, 6q0t – hMAP2K1 in MAPK pathway comples – Cryo EM
    
  • 6whb – hMAP2K1 TOG domain
    
  • 3eqc – hMAP2K1 kinase domain+ATP-Gs+Mg2P
    
  • 3eqd - hMAP2K1 kinase domain (mutant)+ATP-Gs+Mg2P
    
  • 3eqf - hMAP2K1 kinase domain (mutant)+inhibitor+Mg2P
    
  • 3eqg, 3eqi - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd
    
  • 3eqh - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+inhibitor
    
  • 3orn, 4lmn, 3wig - hMAP2K1 kinase domain +MgAMP-PNP +inhibitor
    
  • 3sls – hMAP2K1 kinase domain (mutant) + Mg + AMPPNP + inhibitor
    
  • 4an2, 4an3, 4an9, 4anb – hMAP2K1 kinase domain (mutant) + Mg + ACP + inhibitor
    
  • 3zls, 3zlw, 3zlx, 3zly, 3zm4, 5bx0, 5eym, 5hze, 7pqv – hMAP2K1 kinase domain + inhibitor
    
  • 7xlp, 7xnc – hMAP2K1 kinase domain (mutant) + inhibitor
    
  • 3os3, 3pp1, 3v01, 3v04, 3vvh - hMAP2K1 kinase domain + MgATP +inhibitor
    
  • 7juq – hMAP2K1 kinase domain + ADP
    
  • 4u7z, 4u80, 4u81, 7b3m, 7b7r, 7b94, 7b9l – hMAP2K1 kinase domain + ANP + inhibitor
    
  • 5kkr – hMAP2K1 kinase domain + KSR2 + inhibitor
    
  • 7jur, 7jus, 7jut, 7juu, 7juv, 7juw, 7jux, 7juy, 7juz, 7jv0, 7jv1 – hMAP2K1 kinase domain + KSR2 + ANP-PNP + inhibitor
    
  • 6u2g, 6v2w – hMAP2K1 + BRAF + AMP-PNP
    
  • 6pp9, 7m0t, 7m0u, 7m0v, 7m0w, 7m0x, 7m0y, 7m0z – hMAP2K1 + BRAF + AMP-PNP + inhibitor
    
  • 7mfd – hMAP2K1 + BRAF + KCIP-1 – Cryo EM
    
  • 3eqi - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd
    
  • 3dv3 - hMAP2K1 kinase domain +inhibitor
    
  • 1s9j – hMAP2K1 kinase domain +MgATP+ligand
    
  • 3w8q – hMAP2K1 kinase domain + ATP-γS
    
  • 4mne – hMAP2K1 kinase domain + Mg + ATP-γS + proto-oncogene B-raf
    
  • 6pp9 – hMAP2K1 kinase domain + Mg + AMPPNP + proto-oncogene B-raf
    
  • 6u2g – hMAP2K1 kinase domain + Mg + AMPPCP + proto-oncogene B-raf
    
  • 6q0j, 6q0t – hMAP2K1 kinase domain (mutant) + B-raf + 14-3-3 protein ζ – Cryo EM
    
  • 1sko - hMAP2K1 PB1 domain +P14
    
  • 3cpt - hMAP2K1 PB1 domain +P14 (mutant)
    
  • 1vet, 1veu - mMAP2K1+P14 - mouse
    
  • 2y4i – MAP2K1 + KSR2 + ATP – rabbit
    
• MAP2K2
  • 1s9i – hMAP2K2 kinase domain +MgATP+ligand
    
• MAP2K4
  • 3vut - hMAP2K4 kinase domain
    
  • 3aln - hMAP2K4 kinase domain +AMPPNP
    
  • 3alo - hMAP2K4 kinase domain + P38 peptide
• MAP2K5
  • 2o2v – hMAP2K5 PB1 domain + hMAP3K3B PB1 domain
    
  • 5uoj, 2npt – hMAP2K5+hMAP2KK2
    
  • 4ic7 - hMAP2K4 kinase domain + MAPK7 + AMPPNP
    
  • 1wi0 - mMAP2K5 PB1 domain – NMR
    
  • 7xbr - MAP2K5 – Arabidopsis thaliana
    
• MAP2K6
  • 3vn9 - hMAP2K6
    
  • 3enm – hMAP2K6 (mutant)
    
  • 3fme – hMAP2K6 kinase domain (mutant)
    
• MAP2K7 kinase domain 101-421
  • 5b2k, 5b2l, 5b2m, 6qfl, 6qfr, 6yfz, 6yg0, 6yg1 – hMAP2K7 kinase domain
    
  • 2dyl, 5y8u, 5y90 – hMAP2K7 kinase domain (mutant)
    
  • 3wzu, 6ib0, 6ib2, 6qft, 6qg4, 6qg7, 6qho, 6qhr, 6yg2, 6yg3, 6yg4, 6yg5, 6yg6, 6yg7, 6yz4, 7cbx, 7ovi, 7ovj, 7ovk, 7ovl, 7ovm, 7ovn] – hMAP2K7 kinase domain + inhibitor
    
  • 5z1d, 5z1e – hMAP2K7 kinase domain (mutant) + inhibitor
    
  • 4ux9 - hMAP2K7 kinase domain + MAPK8 + AMPPNP