Crystal structure of 3-HSA hydroxylase from Rhodococcus sp. RHA1Crystal structure of 3-HSA hydroxylase from Rhodococcus sp. RHA1
Structural highlights
2rfq is a 4 chain structure with sequence from Rhojr. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
[HSAA_RHOSR] Catalyzes the o-hydroxylation of 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD. A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1947-52. Epub 2007 Jan 30. PMID:17264217 doi:http://dx.doi.org/10.1073/pnas.0605728104
