2rfq

Crystal structure of 3-HSA hydroxylase from Rhodococcus sp. RHA1Crystal structure of 3-HSA hydroxylase from Rhodococcus sp. RHA1

Structural highlights

2rfq is a 4 chain structure with sequence from Rhojr. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Gene:	hsaA, RHA1_ro04539 (RHOJR)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[HSAA_RHOSR] Catalyzes the o-hydroxylation of 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD. A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1947-52. Epub 2007 Jan 30. PMID:17264217 doi:http://dx.doi.org/10.1073/pnas.0605728104

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OCA

[1] Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD. A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1947-52. Epub 2007 Jan 30. PMID:17264217 doi:http://dx.doi.org/10.1073/pnas.0605728104

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