Mevalonate kinase

Function Mevalonate kinase (MK) is the first enzyme in the mevalonate pathway which synthesizes sterol isoprenoids like cholesterol and non-sterol isoprenoids like ubiquinone. MK catalyzes the conversion of mevalonate to 5-phosphomevalonate. Disease Mutations in MK resulting in MK deficiency cause hyperimmunoglobulinenemia D, a type of severe early-onset colitis, characterized by abdominal pain, diarrhea and vomiting. Structural highlights The 3D structure of MK complex with mevalonate shows the enzyme composed of : The N-terminal and the C-terminal. The mevalonate binds in a between the 2 domains forming . Water molecules are shown as red spheres. . 3D structures of mevalonate kinase Updated on 05-May-2025 2r3v - hMK - human 2r42 - rMK + farnesyl thiopyrophosphate- rat 1kvk - rMK + ATP 4hac - MmMK - Methanosarcina mazei 6mde - MmMK + mevalonate 6mdf - MmMK + 5-phosphomevalonate 1kkh, 1vis - MK - Methancaldococcus jannaschii 2oi2 - MK + diphosphomevalonate - Streptococcus pneumaniae 2hfs - LmMK - Leishmania major 2hfu - LmMK + mevalonate 2x7i - LmMK - Staphylococcus aureus

spinqualitylabelsall models Mevalonate kinase complex with mevalonate (PDB code 2hfu). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image